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The Los Angeles Chargers look to continue their success on the road when they visit the San Francisco 49ers on Sunday Night Football. Los Angeles (5-3) lost its first away game of the 2022 NFL season but has won three straight after posting a 20-17 victory at Atlanta last week. The Chargers are just 3-3 all-time in San Francisco but have won their last two visits. The 49ers (4-4) have played only three home games thus far this year, winning their first two before losing to Kansas City in Week 7.

Kickoff from Levi's Stadium is set for 8:20 p.m. ET. San Francisco is a 7.5-point favorite in the latest 49ers vs. Chargers odds from Caesars Sportsbook, while the over/under for total points scored is 45.5. Before making any Chargers vs. 49ers picks, you need to see the NFL predictions and betting advice from SportsLine's advanced computer model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on 49ers vs. Chargers and just locked in its NFL picks and NFL Week 10 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Chargers vs. Niners:

  • 49ers vs. Chargers spread: San Francisco -7.5
  • 49ers vs. Chargers over/under: 45.5 points
  • 49ers vs. Chargers money line: San Francisco -365, Los Angeles +285
  • SF: 49ers are 6-1 against the spread in their last seven home games
  • LAC: Chargers are 4-0 ATS on the road this season
  • 49ers vs. Chargers picks: See picks at SportsLine

Why the 49ers can cover

San Francisco owns the top-ranked defense in the NFL as it is allowing an average of 285.9 yards. The unit also has been the best against the run, giving up 86.6 yards per game on the ground after limiting the Rams to 56 in the last outing. The 49ers, who are yielding the fewest amount of yards per carry at 3.5, have yet to allow an opposing running back to gain more than 59 yards this season.

Jimmy Garoppolo has recorded at least 300 passing yards just once in eight games since replacing the injured Trey Lance, but he has been making touchdown tosses with regularity of late. The 31-year-old has thrown multiple TD passes in four consecutive contests, the longest streak by a 49ers quarterback since Alex Smith's run in 2009. Garoppolo is looking to become the first San Francisco signal-caller with a five-game run since Jeff Garcia threw for at least two scores in eight straight outings. See which team to back here.

Why the Chargers can cover

Justin Herbert is fifth in the league with 2,254 passing yards despite finishing with fewer than 300 in each of his last four games. However, the 24-year-old has posted 19 300-yard performances in the NFL, tying him with Andrew Luck for the most over his first three seasons since 1950. Herbert, who has failed to throw a touchdown pass in only two of his 40 career contests, guides an aerial attack that ranks fourth with an average of 275.1 yards per game.

Herbert's favorite target this year has been running back Austin Ekeler, who is tied for third in the league with 60 receptions. The 27-year-old Ekeler owns a share of the NFL lead with 10 total touchdowns and has recorded both a rushing and receiving score in four of his last five games, becoming the first player to accomplish the feat since at least 1950. Ekeler has run for 27 TDs and made 28 scoring catches in his career, joining Hall-of-Famer Lenny Moore as the only players in NFL history to register at least 25 of each over their first six seasons. See which team to back here.

How to make 49ers vs. Chargers picks

SportsLine's model is leaning Over on the total, projecting the teams to combine for 50 points. The model also says one side of the spread cashes in well over 50% of simulations. You can only see the model's SNF pick at SportsLine.

So who wins Chargers vs. 49ers on Sunday Night Football? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Chargers vs. 49ers spread you need to jump on, all from the model on a 151-108 roll on NFL picks, and find out.