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The Detroit Lions will take on the San Francisco 49ers at 1 p.m. ET on Sunday at Ford Field. The 49ers are looking to bounce back from a disappointing 6-10 season after winning the NFC Championship the year before. The Lions are looking to avoid a fourth consecutive losing season after finishing 5-11 in 2020. 

San Francisco is favored by 8.5 points in the latest Lions vs. 49ers odds from Caesars Sportsbook, and the over-under is set at 46. Before entering any 49ers vs. Lions picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, the model has set its sights on Lions vs. Niners. You can head to SportsLine to see its picks. Here are several NFL betting lines for Niners vs. Lions:

  • Lions vs. 49ers spread: 49ers -8.5
  • Lions vs. 49ers over-under: 46 points

What you need to know about the 49ers

Injuries played a major role in San Francisco's slide from the top of the NFC last season. The Niners placed an NFL-high 18 players on injured reserve. Nick Bosa suffered a season-ending knee injury in Week 2. Jimmy Garoppolo, who went on IR because of an ankle injury, missed 10 games. Dee Ford was also put on IR because of neck and back issues. 

All three players are ready to return for the 2021 season opener. Garoppolo will start, but No. 3 overall pick Trey Lance could also get mixed in. George Kittle, who was also limited to eight games last season, is ready to go. San Francisco's defense was fourth best in rushing touchdowns allowed last year with 12. 

What you need to know about the Lions

Jared Goff will make his Detroit debut after being traded for longtime Lions signature player Matthew Stafford in the offseason. The former Ram had 14 TDs and six INTs in eight career starts vs. the 49ers. The Lions will play their first game under new head coach Dan Campbell, and Detroit has also revamped its WR crew, with former Raider Tyrell Williams and rookie Amon-Ra St. Brown being among the most notable newcomers. 

T.J. Hockenson led all NFC TEs with a career-high 723 receiving yards. D'Andre Swift had 10 TDs from scrimmage last season. The Lions defense allowed 519 points last year, the third-highest total in league history. 

How to make 49ers vs. Lions picks

The model has simulated Lions vs. 49ers 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins 49ers vs. Lions? And which side of the spread hits more than 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.