USATSI

The San Francisco 49ers can sweep the season series against the Seattle Seahawks for the first time since 2011 when the two NFC West rivals collide on Thursday Night Football game at Lumen Field. In Week 2, the 49ers blew out the Seahawks, 27-7, behind a dominant defensive effort. San Francisco (9-4) would clinch the NFC West title with a victory on TNF. Meanwhile, Seattle (7-6) is in a dogfight for the third and final wild card spot in the NFC playoff picture. The Seahawks enter Thursday just behind the Commanders and Giants (both 7-5-1) for the last postseason spot. 

Kickoff from Lumen Field is set for 8:15 p.m. ET. San Francisco is a three-point favorite in the latest 49ers vs. Seahawks odds from Caesars Sportsbook, while the over/under for total points scored is 43. Before making any Seahawks vs. 49ers picks, you need to see the NFL predictions and betting advice from SportsLine's Advanced Computer Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks. 

The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on 49ers vs. Seahawks and just locked in its picks and Thursday Night Football predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Seahawks vs. 49ers: 

  • 49ers vs. Seahawks spread: San Francisco -3
  • 49ers vs. Seahawks over/under: 43 points 
  • 49ers vs. Seahawks money line: San Francisco -190, Seattle +158
  • SF: 49ers are 2-8-1 against the spread in their last 11 games at Seattle 
  • SEA: Seahawks are 8-2-2 ATS in their last 12 Thursday contests 
  • 49ers vs. Seahawks picks: See picks here

Why the 49ers can cover

San Francisco arguably has the best defense in the league. Led by relentless attack man Joey Bosa, the 49ers lead the league in both scoring defense (15.2 points per game) and total defense (286.8 yards per game). The 15.2 points per game average is the second best of any team since the start of the 2014 season, behind only the 2019 Patriots (14.1). Bosa is tied for the NFL lead in sacks (14.5) and has at least one sack in six of his last seven games.

In addition, running back Christian McCaffrey has found his stride with San Francisco. Over the last six games, the former Panthers star has 680 yards from scrimmage and scored six touchdowns. Last week, he had his best game since being traded to the 49ers, with 119 rushing yards and two touchdowns from scrimmage. See which team to pick here.

Why the Seahawks can cover

Seattle is sixth in scoring after finishing in the middle of the pack last season, and quarterback Geno Smith has been a major reason for the improvement. The Seahawks are averaging 26.3 points with Smith serving as a starting quarterback for the first time since 2014 with the New York Jets. The 32-year-old ranks third in the league with a 106.8 passer rating, fourth with 25 touchdown tosses and sixth with 3,433 passing yards, the latter two being career-highs and the former on track to be a personal best.

Smith has one of the top receiving duos with which to work, Tyler Lockett and DK Metcalf, who are both on pace for 1,000-yard seasons. Lockett, who is seeking his fourth straight 1,000-yard campaign, leads Seattle with 896 yards on 71 receptions, while Metcalf has a team-high 72 catches for 869 yards. The 30-year-old Lockett, who is six years older, had hauled in a touchdown pass in a franchise-record six consecutive games and is first on the club with eight scoring catches, while Metcalf has six. See which team to pick here.

How to make 49ers vs. Seahawks picks on TNF

SportsLine's model is leaning Over the point total, calling for 44 combined points. The model also says one side of the spread hits in over 50% of simulations. You can only see the model's TNF picks at SportsLine.

So who wins Seahawks vs. 49ers on Thursday Night Football? And which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the Seahawks vs. 49ers spread you need to jump on, all from the model on a 157-113 roll on NFL picks, and find out.