Best betting apps, NFL sportsbooks promos for Monday Night Football: How, where to bet 49ers vs. Colts
San Francisco vs. Indianapolis takes place on Monday Night Football, and bettors can use NFL sportsbook promos at the best NFL betting sites and NFL betting apps

The Indianapolis Colts (8-6) host the San Francisco 49ers (10-4) on Monday Night Football to wrap up the Week 16 NFL schedule. The Colts need a win on Monday to keep pace with the Texans, who defeated the Raiders, 23-21, on Sunday to improve to 10-4 on the season and currently hold the final AFC wild card position. The 49ers have clinched a playoff berth, but they can still win the division and potentially capture the No. 1 seed in the conference with a strong finish. The 49ers are 5.5-point favorites, according to the latest 49ers vs. Colts odds, with an over/under of 46 points.
There are dozens of betting options if you're wondering how to bet on the NFL, or more specifically, 49ers vs. Colts. Here's a closer look at available sportsbook promos on some of the top NFL betting sites, as well as the best betting apps that are available for Colts vs. 49ers on Monday Night Football, with instructions on how to claim each offer and where to bet NFL.
Where to bet on the NFL on 49ers vs. Colts on Monday Night Football
The DraftKings promo code, bet365 bonus code and FanDuel promo code all offer bonus bets after new users place a wager of $5 or more. The bet365 bonus code CBSSPORTS offers new users $150 in bonus bets with the placement of a $5+ bet, whether the bet wins or loses.
At DraftKings and FanDuel, you need to win your first bet to receive the bonus. FanDuel offers new users $250 in bonus bets if their first bet of at least $5 wins. DraftKings offers $200 in bonus bets with a winning wager of at least $5.
The latest Fanatics Sportsbook promo code CBSFAN provides new users who place a cash wager of at least $1 on any market with odds of -500 or longer up to $200 in FanCash per day every day for ten (10) consecutive days, if the initial wager settles as a loss. This promotion is available to eligible users in states where Fanatics Sportsbook legally operates (except New York).
The latest BetMGM bonus code CBSSPORTS awards new users up to $1,500 back in bonus bets if their first bet loses. BetMGM users in New Jersey, West Virginia, Pennsylvania or Michigan can get a different promotion and receive $150 in bonus bets if you win your first bet of $10 or more.
The Caesars Sportsbook promo code CBS250BM matches your first bet up to $250 as a bonus bet, whether it wins or loses. After placing a qualifying wager with odds of -500 or longer, users will receive bonus bets equal to the amount of the first wager, up to $250.
Bettors can use any of these promotions for Colts vs. 49ers NFL betting for Monday Night Football on Monday, December 22.
49ers vs. Colts betting preview, picks
Colts (+5.5) vs. 49ers
The Colts nearly knocked off the Seahawks as 14-point underdogs last week, keeping the best team in the NFC out of the end zone the entire contest in an 18-16 final. Seattle won on a 56-yard field goal with 18 seconds left, so if the Colts can frustrate the Seahawks enough for a two-point final score on the road, they can certainly create problems for the 49ers at home. Philip Rivers has his first start since 2020 out of the way, and the 44-year-old was effective enough to keep the Colts in the contest. The model expects Indianapolis to compete again on Monday, projecting the Colts to cover in 53% of simulations. Back the Colts at BetMGM, where new users get up to $1,500 in bonus bets if your first bet loses:
Over 46 points
The 49ers are averaging 31 points per game over their last four contests, and they are 10th in the league in scoring at 24.6 ppg this season. San Francisco scored 37 points last week, while allowing 24 points to the Titans, who rank 30th in the league at 16.7 ppg. If the Titans can score 24 points against the 49ers, the Colts should be able to move the ball as well to help this game reach the Over. Jonathan Taylor rushed for 87 yards last week for the Colts, and is one of the best backs in the league. The 49ers have one of the best skill position groups in the NFL, highlighted by Christian McCaffrey, George Kittle and Jauan Jennings, and with Brock Purdy back, healthy and efficient at quarterback, the model projects offensive success on Monday. The Over hits in 60% of the model's simulations. Back the Over at Caesars Sportsbook, where your first bet is matched up to $250 in bonus bets:
Responsible gaming
Responsible gaming is a serious topic, and all sportsbooks take steps to ensure users play responsibly. The top sportsbooks feature several tools and resources available on their apps and websites, including wager limits, voluntary self-exclusion options, and more. If you or someone you know is dealing with a gambling problem, please seek assistance from trained professionals such as the Problem Gambling Help Network at 1-800-GAMBLER.
















