Bills vs. Bears odds, start time, pick, line, spread, how to watch, live stream: 2022 Week 16 NFL predictions
SportsLine's model just revealed its NFL picks for Chicago Bears vs. Buffalo Bills

A frigid Saturday matchup between the Chicago Bears and Buffalo Bills is on tap in Week 16, and you can catch Josh Allen vs. Justin Fields on CBS and Paramount+. The forecast is calling for a wind chill near -20 and steady winds of over 20 m.p.h., so both running quarterbacks may have to tap into their natural running ability. Chicago (3-11) will try to snap a seven-game losing streak, while Buffalo (11-3) can wrap up the AFC East title with a win.
Kickoff is scheduled for 1 p.m. ET at Soldier Field. Buffalo is favored by eight points in the latest Bills vs. Bears odds from Caesars Sportsbook, and the over/under is 40.5. You can stream the game in select markets on Paramount+, and you can get your first year for 50% off when you use promo code ALLYEAR from now until 12/31.
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How to watch Bills vs. Bears
- Bills vs. Bears spread: Bills -8
- Bills vs. Bears over/under: 40.5 points
- Bills vs. Bears money line: Buffalo -400, Chicago +310
- Bills vs. Bears streaming: Paramount+ (use promo code ALLYEAR for half-off your first year)
Week 16 NFL picks for Bears vs. Bills
Before tuning into Saturday's Bills vs. Bears game, you need to see the NFL picks from SportsLine's advanced computer model. The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
For Bears vs. Bills, the model is backing the Buffalo Bills to cover. Buffalo is the current No. 1 seed in the AFC playoff picture, with Josh Allen leading the Bills on a five-game winning streak entering Week 16. Allen is coming off a high-octane performance in brutal weather conditions a week ago, throwing for 304 yards and four touchdowns while also rushing for 77 yards in a win over the Dolphins in heavy snow.
With Stefon Diggs blanketed and throwing down the field being a struggle, tight end Dawson Knox served as a reliable safety valve over the middle. He finished with six receptions for 98 yards and a touchdown. The Bills also ran for 150 yards as a team against a stout Miami front and should have their way with a Chicago run defense that ranks 27th in the NFL.
The model is predicting that the Bills pile up over 160 yards on the ground on Saturday to help Buffalo cover the spread in well over 50% of simulations. With both teams accustomed to playing in difficult conditions, the model is also predicting that over 40.5 points his in nearly 60% of simulations.
How to watch, live stream the NFL on CBS
Now that you know what to pick, get ready to watch your live local NFL on CBS games on Paramount+ on any device you want. Visit Paramount+ now to stream your live local CBS sporting events, including the NFL, SEC on CBS, and so much more. Get your first year for 50% off with the promo code ALLYEAR here.















