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Taylor Heinicke and the Washington Commanders (3-4) hit the road to take on Sam Ehlinger and the Indianapolis Colts (3-3-1) in a Week 8 matchup at 4:25 p.m. ET at Lucas Oil Stadium in Indianapolis. Heinicke is starting for Washington in place of Carson Wentz, who is on Injured Reserve with a finger injury. He won his first start of the season against the Green Bay Packers 23-21 in Week 7. Ehlinger is taking over for 2016 NFL MVP Matt Ryan, who was benched following the Colts' 19-10 loss to the Tennessee Titans in Week 7. Both teams are 3-4 against the spread in 2022.

Kickoff is at 4:25 p.m. ET. Indianapolis is favored by 3 points in the latest Colts vs. Commanders odds from Caesars Sportsbook, and the over/under is set at 39.5 points. Before making any Commanders vs. Colts picks, you need to see the NFL predictions and betting advice  from the proven simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 8 of the 2022 NFL season on an incredible 148-107 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Commanders vs. Colts and just locked in its picks and NFL Week 8 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Colts vs. Commanders:

  • Colts vs. Commanders spread: Colts -3
  • Colts vs. Commanders over/under: 39.5 points
  • Colts vs. Commanders money line: Indianapolis -150, Washington +126
  • Colts vs. Commanders picks: See picks here

What you need to know about the Commanders

it was a close one, but this past Sunday Washington sidestepped the Green Bay Packers for a 23-21 victory. No one had a standout game offensively for Washington, but the Commanders got scores from WR Terry McLaurin and RB Antonio Gibson. Heinicke ended up with a passer rating of 125.70 in his first start in place of Wentz.

Washington has battled inconsistencies on both sides of the ball, but Heinicke provided a spark that the offense seemed to have been missing all year. The veteran backup guide the Commanders to one of their most productive offensive games of the season and had a noticeable rapport with explosive wide receiver Terry McLaurin. 

What you need to know about the Colts

The Colts have opted to move in a different direction, benching Ryan in favor of Ehlinger. Ryan guided the Colts to a 3-3-1 record, completing 68.4% of his passes for 2,008 yards, 9 touchdowns, 9 interceptions, and a quarterback rating of 84.7 along the way. Ryan suffered a shoulder injury against the Titans in Week 7, but the Colts have made it clear that the plan is to go with Ehlinger for the remainder of the season.

Ehlinger is a 2021 sixth-round draft pick out of Texas, who impressed during his game action in back-to-back preseasons. He appeared in three games as a rookie in 2021, but has yet to attempt a pass at the NFL level. During his time at Texas, Ehlinger proved to be a dual-threat quarterback, rushing for 1,903 yards and 33 touchdowns during his career in Austin.

How to make Colts vs. Commanders picks

The model has simulated Commanders vs. Coltss 10,000 times and the results are in. The model is leaning Over on the point total, and it also says one side of the spread hits more than 50% of the time. You can only see the model's pick at SportsLine.

So who wins Colts vs. Commander? And which side of the spread hits more than 50% of the time? Visit SportsLine right now to find out which side of the Commanders vs. Colts spread you should be all over, all from the model on a 148-107 roll on its top-rated NFL picks, and find out.