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A divisional battle takes place on 'Thursday Night Football' as the Seattle Seahawks host the Los Angeles Rams at 8:15 p.m. ET. With Jaxon Smith-Njigba and Puka Nacua ranking first and second, respectively, in receiving yards, NFL DFS stacks with their respective quarterbacks will be a popular daily Fantasy football strategy. However, Sam Darnold had four picks when these teams met in Week 11, while Matthew Stafford had just 130 passing yards. So, your NFL DFS strategy shouldn't bypass the ground games as both squads use multiple running backs.

Potential NFL DFS picks out of the backfield include Kenneth Walker III, Zach Charbonnet, Kyren Williams and Blake Corum. It's all about getting the most value relative to cost when choosing options from the TNF DFS player pool. Before making any Rams vs. Seahawks DFS picks on sites like FanDuel or DraftKings for 'Thursday Night Football', be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure. 

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him could be way up.

Now, McClure has turned his attention to the 'Thursday Night Football' DFS slate and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine. 

Top NFL DFS picks for Seahawks vs. Rams

One of McClure's top NFL DFS picks for 'Thursday Night Football' is Rams wideout Puka Nacua. Despite missing one full game, and half of another, Nacua is second in the NFL in both receptions (102) and receiving yards (1,367). The third-year receiver is coming off his best game as a pro with a career high of 181 yards on Sunday versus Detroit, which came just a week after posting a 7-167-2 stat line. Nacua had 93 total yards versus Seattle in their matchup earlier this year, and he will be just fine if Davante Adams (hamstring) can't play as Nacua ranked third with 90 receiving yards per game last year without Adams on the team. See who else to roster at SportsLine. 

Bet Nacua to go Over 7.5 receptions at DraftKings, where new users can target the DraftKings promo code, which offers $200 in bonus bets if your bet wins:

McClure is also rostering Seahawks tight end AJ Barner, who was heavily featured in Week 11 versus the Rams. He had season highs in targets (11) and receptions (10), while his 70 receiving yards were one shy of matching his career high of 71. For the season, Barner has scored 5 touchdowns as part of his 43 catches and 413 receiving yards. With the Rams having a top-10 run defense, and allowing the fewest rushing touchdowns of any team, as opposed to the No. 19 pass defense, Seattle could lean on an aerial attack. That boosts Barner's value, who also scored a touchdown in his last game versus the Rams in the 2024 season. See who else to roster at SportsLine. 

Bet Barner to go Over 32.5 receiving yards at DraftKings:

How to set Rams vs. Seahawks DFS lineups

McClure is targeting another undervalued player who could explode for huge numbers on 'Thursday Night Football.' This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure's NFL DFS picks, at SportsLine.

So who is Mike McClure including in his optimal NFL DFS lineups for 'Thursday Night Football', and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.