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The NFL playoff picture will begin to take shape as the NFL schedule enters Week 16. The NFC North title may be on the line on Saturday night when Jordan Love and the Green Bay Packers take on Caleb Williams and the Chicago Bears. The Bears hold a half-game lead over the Packers in the division. Green Bay is a 1.5-point road favorite and is 3-6-1 against the spread in its last 10 games, while Chicago is 7-2-1 ATS in its last 10. The Packers won the last meeting, 28-21, in Green Bay on Dec. 7, and have won nine of the past 10 meetings with the Bears. Green Bay will be without several starters due to injury, including pass rusher Micah Parsons (knee) and possibly wide receiver Christian Watson (chest).

There are a number of other intriguing matchups on the Week 16 NFL schedule, including Rams (-1.5) vs. Seahawks on Thursday Night Football; Buccaneers (-2.5) vs. Panthers, Jaguars vs. Broncos (-3) and Steelers vs. Lions (-7) on Sunday; Patriots vs. Ravens (-2.5) on 'Sunday Night Football' and 49ers (-5.5) vs. Colts on 'Monday Night Football.' Before locking in any Week 16 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 on a 52-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has scoured the Week 16 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of nearly 25-1. You can only see the model's Week 16 NFL picks at SportsLine.

Top Week 16 NFL picks

After simulating every game 10,000 times, the model is high on the Denver Broncos (-3, 45.5) to cover against the Jacksonville Jaguars on Sunday afternoon. Bet our Broncos vs. Jaguars SGP at DraftKings below, and see our 25-1 Week 16 NFL parlay at SportsLine.

The Broncos are led by quarterback Bo Nix. In 14 games this season, he has completed 63.5% of his passes for 3,256 yards and 23 touchdowns with nine interceptions and an 89.7 rating. He has also rushed 62 times for 254 yards (4.1 average) and four touchdowns. In a 34-26 win over the Green Bay Packers in Week 15, he completed 23 of 34 passes for 302 yards and four touchdowns.

The model has Denver winning outright well over 60% of the time and covering in well over 50% of simulations in an A-rated spread pick. See which other NFL parlay picks to make here.

How to make Week 16 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will easily cover. You can only see the model's Week 16 NFL best bets and NFL parlay at SportsLine.

What are the model's top Week 16 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 16 NFL best bets from a model on a 52-37 run on top-rated picks, and find out.