Lewis (ankle) has been upgraded and carries no injury designation ahead of Sunday's matchup against the Seahawks.
The 30-year-old practiced in full Friday, and despite his original questionable designation, he'll suit up for the Week 15 matchup. Lewis has underwhelmed through nine appearances this season, recording just eight total tackles, including 3.0 sacks, and one pass defensed. Now fully healthy, he's expected to operate as one of the Colts' top reserve defensive ends Sunday.
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Colts' Tyquan Lewis: Questionable to face Seattle
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Lewis (ankle) is listed as questionable ahead of Sunday's game against the Seahawks.
Lewis was absent for the Colts' Week 14 loss, but he progressively increased his practice involvement ahead of Sunday's game against Seattle. He upgraded to a full session Friday but will remain questionable for the time being.
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Colts' Sauce Gardner: Won't return for Week 15
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Gardner (calf) has been ruled out ahead of Sunday's matchup against the Seahawks.
The fourth-year pro from Cincinnati didn't practice Wednesday or Thursday and is now in line to miss his second consecutive game due to a non-contact calf injury. While Gardner remains sidelined in Week 15, expect Mekhi Blackmon and Johnathan Edwards to operate as Indianapolis' top boundary cornerbacks.
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Colts' DeForest Buckner: Won't return Sunday
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Buckner (neck) has been ruled out ahead of Sunday's matchup against the Seahawks, JJ Stankevitz of the Colts' official site reports.
The veteran defensive lineman returned to practice this week after missing the Colts' last four contests due to a neck injury, but it appears he's not ready for game action just yet. Through nine appearances this season, Buckner has tallied 42 total tackles, including 4.0 sacks, across 424 defensive snaps. While he remains on the injured reserve list Sunday, Neville Gallimore will likely start on Indianapolis' defensive line.
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Colts' DeForest Buckner: Window to return from IR opens
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Buckner (neck) had his 21-day practice window opened Wednesday, Mike Chappell of FOX 59/CBS 4 Sports reports.
Buckner will be a limited participant at practice Wednesday, per Stephen Holder of ESPN.com. The defensive tackle has been on injured reserve since Nov. 7. The Colts have 21 days to add Buckner back to the active roster, and such a move could transpire prior to Sunday's game against the Seahawks, though he would presumably need to upgrade to full practice participation without any setbacks first.
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Colts' Charvarius Ward: Won't return in regular season
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Ward (concussion) was placed on injured reserve Wednesday.
Ward will miss the remainder of the regular season, but he will be eligible to return for the playoffs, should the Colts make it. He would need to clear the NFL's five-step concussion protocol to resume playing at that point. Ward finishes the 2025 regular season with 25 tackles (17 solo) and seven passes defensed in seven appearances.
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Colts' Zaire Franklin: Posts seven stops vs. Jacksonville
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Franklin registered seven tackles (two solo) during the Colts' 36-19 loss to the Jaguars on Sunday.
Franklin was one of three Colts defenders to play every single snap, and he led the team in tackles for a second consecutive game. The 2018 seventh-rounder is up to 94 combined stops through 13 regular-season games, and he should crack the tackling century mark for a fourth consecutive year. That could come as soon as this Sunday against the Seahawks.
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Troy Pride: Links up with practice squad
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Pride signed with the Colts' practice squad on Tuesday, Howard Balzer of USA Today reports.
Pride played two games for the Cowboys last season and recorded three tackles (two solo) and a pass breakup over 56 defensive snaps. He'll provide some depth to the banged-up Colts secondary as they make their playoff push.
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Colts' Chris Lammons: Moved to injured list
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The Colts placed Lammons (foot) on injured reserve Tuesday, JJ Stankevitz of the team's official site reports.
Lammons suffered a foot injury against the Jaguars last Sunday and was unable to return to the game. The injury is severe enough to land the cornerback on IR, and he will be unable to return until a potential postseason game at the earliest. In corresponding moves, the Colts signed cornerback Cameron Mitchell to the 53-man roster and signed cornerback Troy Pride to the practice squad. Mitchell will likely replace Lammons, backing up Kenny Moore in the slot cornerback role.
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Colts' Nick Cross: Posts five stops in Week 14 loss
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Cross finished Sunday's loss to Jacksonville with five tackles (three solo) and two defensed passes.
Cross was Indianapolis' third-leading tackler in the tough loss. He also notched multiple defensed passes for the first time this season. Cross has posted at least five tackles in all but one of his 13 contests on the campaign and is up to 89 stops, including 2.5 sacks, overall.
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Colts' Chris Lammons: Won't return vs. Jacksonville
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Lammons (foot) has been ruled out for the remainder of Indianapolis' matchup versus the Jaguars on Sunday.
Lammons is done for the day after suffering a foot injury in the first half. The 29-year-old had seen the majority of his playing time on special teams before exiting the game, so his absence likely won't affect the Colts' defensive gameplan.
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Colts' Chris Lammons: Questionable to return
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Lammons (foot) is questionable to return in Sunday's game against the Jaguars.
Lammons exited in the first half of Sunday's Week 14 game against the Jaguars with the injury. The 29-year-old saw most of his workload on special teams before the injury but did see an uptick in playing time with Sauce Gardner out. Mekhi Blackmon and George Odum may see larger roles if Lammons remains out.
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Colts' Tyquan Lewis: Ruled out for Week 14
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Lewis (ankle) has been ruled out for Saturday's game versus the Jaguars.
Lewis will miss his fourth game of the season, this time due to an ankle injury that he seemingly picked up earlier in the week. Samson Ebukam and JT Tuimoloau should see increased playing time against Jacksonville in Lewis' absence.
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Colts' Jaylon Carlies: Chance to be activated from IR
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Carlies (ankle) is listed as questionable for Sunday's game against the Jaguars.
Carlies was a full participant in practice all week, and while he's tagged as questionable, he is trending toward being activated from injured reserve and being cleared to make his 2025 regular-season debut Sunday. The second-year linebacker is in the final stages of his recovery from an ankle injury he sustained during the preseason in early August. Carlies would likely work in a rotational role at linebacker while contributing on special teams if he's activated from IR.
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Colts' Tyquan Lewis: Tagged as questionable Week 14
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Lewis (ankle) is listed as questionable for Sunday's game against the Jaguars.
Lewis registered a DNP-LP-DNP practice log during Week 14 prep while working through an ankle injury. His status for Sunday's AFC South tilt may not be officially known until 90 minutes prior to the 1:00 p.m. ET kickoff, when the Colts announce their list of inactive players. Samson Ebukam and JT Tuimoloau would be in line for more rotational snaps at defensive end behind Kwity Paye and Laiatu Latu if Lewis is not cleared to play.
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Colts' Kenny Moore: Upgrades to full participation
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Moore (illness/ankle) was a full participant in Thursday's practice.
Moore upgraded to full participation Thursday after not practicing Wednesday due to an illness. The starting slot cornerback will be good to go for Sunday's divisional matchup with the Jaguars, a game that could be pivotal in determining the winner of the AFC South.
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Colts' Tyquan Lewis: Limited in practice Thursday
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Lewis (ankle) was a limited participant in Thursday's practice.
Lewis has logged less than 30 percent of defensive snaps in his last two outings after returning from a groin injury, and he's now been saddled with an ankle injury. The defensive end's upgrade to limited participation is a good sign that he will be able to suit up for a third consecutive game, though he'll likely continue to see a similar amount of playing time.
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Colts' Kenny Moore: Dealing with illness
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Moore (illness/ankle) was listed as a non-participant during Wednesday's walkthrough.
Moore was listed on the injury report with this ankle injury last week, but he was still a full practice participant. Thus, it's likely that Moore's illness is what's keeping him out of practice instead of the ankle issue. Moore has posted 36 tackles (20 solo), five pass breakups, 1.5 sacks and a pick-six through nine games. Chris Lammons likely will start at slot cornerback if Moore can't play Sunday versus the Jaguars.
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Colts' Tyquan Lewis: No practice Wednesday
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Lewis (ankle) was listed as a non-participant for Wednesday's practice.
Lewis missed three straight games with a groin injury before returning for the last two weeks, although he logged less than 30 percent of the defensive snaps in each outing. Now, he's back on the injury report with an ankle injury. Getting on the field for Thursday's practice will be crucial to his chances to play Sunday versus the Jaguars.
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Colts' Nick Cross: Logs six stops vs. Houston
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Cross posted six tackles (four solo) during the Colts' 20-16 loss to the Texans on Sunday.
Cross was one of four Colts defenders to play all 76 defensive snaps during Sunday's loss, and he has played every single defensive snap in six of 12 regular-season games. The fourth-year safety is up to 83 total tackles on the year and is within striking distance of eclipsing the tackling century mark for a second consecutive season.