The Colts placed Key (hamstring) on injured reserve Saturday.
Key sustained a hamstring injury against the Colts in Week 4, and the injury is severe enough for the veteran defensive lineman to warrant a stint on IR. He'll be required to miss at least four games, so the earliest Key can return is Week 9 against the Cowboys on Sunday, Nov. 8. Laiatu Latu, Jaylahn Tuimoloau and rookie fifth-rounder George Gumbs are all in line for more defensive snaps in Key's absence.
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Colts' Jaylon Carlies: Ruled out for Week 5
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Carlies (ribs) has been ruled out ahead of Sunday's game against the Steelers.
Carlies was unable to practice throughout the Colts' Week 5 prep. The weakside linebacker injured his ribs in the team's Week 4 win over the Commanders in London. Tahj Chambers or Austin Ajiake will start at weakside linebacker in Carlies' absence.
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Colts' Charvarius Ward: Questionable for Week 5
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Ward (groin) is listed as questionable for Sunday's game against the Steelers.
Ward registered an LP-LP-FP practice log, and while he's been tagged as questionable, he's probably closer toward probable for Sunday's game given his full practice participation Friday. If he's not cleared to play, then Cam Taylor-Britt would be the top candidate to start opposite Sauce Gardner at outside cornerback.
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Colts' Akeem Davis-Gaither: Logs full practice Thursday
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Davis-Gaither (knee) was a full participant at practice Thursday.
Davis-Gaither popped up on the Colts' injury report with a knee issue Wednesday, but it doesn't look like it was anything too serious, and he's back on track to suit up in Week 5. He projects as a solid IDP option in most formats going into Sunday's contest against the Steelers.
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Colts' Akeem Davis-Gaither: Working through knee injury
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Davis-Gaither was a non-participant in Wednesday's practice due to a knee injury.
Davis-Gaither played all but two of the Colts' defensive snaps during their Week 4 win over the Commanders in London, finishing with eight tackles (five solo). The veteran linebacker appears to have picked up the knee injury in the process, and he'll have two more chances to return to practice ahead of Sunday's road game against the Steelers.
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Colts' Jaylon Carlies: Sits out practice with rib injury
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Carlies didn't practice Wednesday due to a rib injury.
Carlies injured his ribs toward the tail end of the Colts' Week 4 win over the Commanders in London, logging five tackles (three solo) and an interception before leaving the game late in the third quarter. He'll have two more opportunities to return to practice, but if he's not cleared to play against the Steelers on Sunday, rookie second-round pick CJ Allen could end up serving as his primary replacement.
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Colts' Akeem Davis-Gaither: Records eight stops against Washington
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Davis-Gaither tallied eight tackles (five solo) during the Colts' 30-13 win over the Commanders on Sunday in London.
Davis-Gaither played 62 of 64 defensive snaps during Sunday's win and co-led the Colts in tackles with Justin Walley. Davis-Gaither has logged at least seven total tackles in each of the first four games of the regular season, and his 37 stops lead the Colts and are tied for sixth-most in the NFL.
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Colts' Jaylon Carlies: Hauls in first career interception
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Carlies (undisclosed) logged five tackles (three solo) and an interception during Sunday's 30-13 win over the Commanders in London.
Carlies set the Colts up in Commanders territory after picking off Athan Kaliakmanis early in the third quarter, leading to a five-yard rushing touchdown by Jonathan Taylor four plays later. Carlies picked up an undisclosed injury in the same period and was ruled out during the fourth quarter, so Wednesday's practice report will shed some light on his status ahead of the Colts' Week 5 road tilt against the Steelers.
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Colts' Justin Walley: Secures first-career sack
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Walley recorded eight tackles (five solo), including 1.0 sacks, during the Colts' 30-13 win over the Commanders on Sunday in London.
Walley briefly left Sunday's game early in the third quarter due to an undisclosed injury but was back on the field for the Colts' next defensive drive, and he sacked QB Athan Kaliakmanis for a nine-yard loss later in the same period. It was the first sack of Walley's NFC career, and he has 22 tackles (15 solo) and three pass defenses through four regular-season games.
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Colts' Arden Key: Set to miss time
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Colts head coach Shane Steichen said Tuesday that Key is expected to miss three to four weeks with a hamstring injury, per Jeremy Fowler of ESPN.com.
Key's availability was already in doubt for Week 5 after sustaining a hamstring injury in Sunday's win over Washington, he's now set to miss the next three to four weeks for the Colts. JT Tuimoloau and Caden Curry will increase reps on the defensive line while Key is out.
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Colts' DeForest Buckner: Gets to Stroud twice in Week 3 win
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Buckner registered seven tackles (two solo), including 1.5 sacks, during the Colts' 19-17 win over the Texans in Week 3.
Buckner was responsible for two of the Colts' three sacks on C.J. Stroud in Sunday's win. The veteran defensive lineman got to Stroud early in the first quarter for a four-yard sack before Buckner combined with Adetomiwa Adebawore for a two-yard takedown of the Texans QB late in the second quarter. Buckner has logged at least 0.5 sacks in each of the first three games of the regular season and is up to 3.0 sacks on the year, which leads the Colts and is tied for eighth-most in the NFL.
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Colts' Laiatu Latu: Returns to Sunday's game
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Latu (chest) has returned to Sunday's game against the Texans, Kevin Bowen of 107.5 The Fan Indianapolis reports.
Latu left for the locker room in the first half due to a chest injury, but he was back on the field for the Colts in the third quarter. Latu has yet to record a tackle.
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Colts' Laiatu Latu: Exits game with chest injury
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Latu is questionable to return to Sunday's game against the Texans due to a chest injury, James Boyd of The Athletic reports.
Latu briefly returned to the game before leaving the field for the locker room, where he'll undergo further tests on his chest to determine whether he can return to Sunday's game. Caden Curry and JT Tuimoloau are both in line for more snaps on defense for as long as Latu is out of the game.
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Colts' Charvarius Ward: Cleared to play against Houston
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Ward (groin) is active for Sunday's game against the Texans.
Ward tweaked his groin during the Colts' overtime loss to the Chiefs in Week 2. He drew the questionable tag for Sunday's AFC South tilt following a DNP-LP-FP practice log, and the veteran cornerback has been given the green light to play after going through pregame warmups. Cam Taylor-Britt will operate in a depth role behind Ward and Sauce Gardner for Week 3.
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Colts' Charvarius Ward: Could play against Houston
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Ward (groin) is listed as questionable for Sunday's game against the Texans, Adam Caplan of SiriusXM NFL Radio reports.
Ward drew the questionable tag for Week 3 following a DNP-LP-FP practice log. He's working through a groin injury that he picked up in Week 2 against the Chiefs, and if he cannot play Sunday, then Cam Taylor-Britt would likely start at outside cornerback opposite Sauce Gardner.
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Colts' Charvarius Ward: DNP with groin injury
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Ward (groin) did not participate in Wednesday's practice.
Ward exited Sunday's 33-30 overtime loss to the Chiefs early due to groin tightness. The starting cornerback will likely need to upgrade his practice participation to at least a limited level by Friday to have a chance of playing in the Colts' Week 3 divisional matchup against the Texans.
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Colts' Akeem Davis-Gaither: Secures 14 tackles in defeat
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Davis-Gaither recorded 14 total tackles (seven solo) during Sunday night's 33-30 overtime loss to the Chiefs.
Davis-Gaither was a very busy man in Week 2, securing a new career-high 14 takedowns in the contest. The linebacker notched a career-best 117 total tackles over 17 regular-season games with Arizona in 2025, and he is now off to a hot start in his first campaign with the Colts. Through two games, Davis-Gaither has compiled 22 total tackles (12 solo) this season.
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Kenny Moore: Joins forces with Eagles
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Moore agreed Tuesday to sign with the Eagles' practice squad, Zach Berman of The Athletic reports.
Per Mike Garafolo of NFL Network, Moore will eventually be promoted to the Eagles' 53-man roster and will receive a one-year, $3 million deal. A 2021 Pro Bowl selection, Moore spent most of his past nine seasons in Indianapolis as a slot corner, but he's expected to see snaps both at that position and at safety once he joins the Eagles.
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Colts' Charvarius Ward: Nursing groin issue
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Ward is dealing with groin tightness after Sunday night's 33-30 overtime loss to the Chiefs, Jake Arthur of Roundtable.io reports.
Ward exited the game with groin discomfort in the second half, but he appears to have avoided a significant injury. The cornerback's status at the team's first practice of the week Wednesday will provide more clarity towards his availability for Week 3 versus the Texans.
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Colts' Micheal Clemons: Dealing with toe injury
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Clemons (toe) is questionable to return to Sunday night's contest against Kansas City.
Clemons suffered a toe injury at some point during the second half of the contest, and his availability for the rest of the game is now unclear. In his absence, JT Tuimoloau could see an increase in opportunities on the defensive line.
