Head coach Kyle Shanahan said Monday that Bosa (calf) "has a chance" to play against the Commanders next Monday night, David Lombardi of SFStandard.com reports.
Bosa has missed the 49ers' last three games while tending to a calf injury. While he could return against Washington, Bosa's practice participation during Week 6 prep will ultimately determine whether he's cleared by medical staff to suit up. Mykel Williams and Romello Height will continue to get more reps at defensive end for as long as Bosa is sidelined.
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49ers' Garret Wallow: Headed for multi-game absence
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San Francisco head coach Kyle Shanahan said Monday that Wallow will miss "at least a couple of weeks" due to a hamstring strain, Nick Wagoner of ESPN.com reports.
Shanahan seemingly ruled out the reserve linebacker through the 49ers' Week 8 bye, with Wallow expected to sit out Week 6 versus the Commanders as well as Week 7 in Atlanta. Wallow has accrued seven tackles (five solo) this season while seeing the majority of his playing time on special teams.
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49ers' Dre Greenlaw: Draws one-game suspension
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Greenlaw was handed a one-game suspension without pay Monday for an act of unsportsmanlike conduct during Sunday's 32-29 win over the Seahawks, Tom Pelissero of Netflix reports.
The suspension stems from an incident that occurred midway through the second quarter, when Greenlaw was involved in a skirmish on the Seattle sideline and used his helmet to headbutt the Seahawks' Ernest Jones, who wasn't wearing a helmet. Per Ian Rapoport of NFL Network, Greenlaw will appeal the suspension, but his history -- with the Broncos last season, he also received a one-game ban for unsportsmanlike conduct -- may work against him in getting the suspension overturned. Barring a successful appeal, the veteran linebacker will miss the 49ers' Week 6 game against the Commanders before returning to action Oct. 25 versus the Falcons.
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49ers' Renardo Green: Picks off Darnold twice in Week 5 win
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Green logged one solo tackle and three pass defenses (including two interceptions) during the 49ers' 32-29 win over the Seahawks on Sunday.
Green's first interception off Sam Darnold came on the Seahawks' third offensive play of the first quarter, which set up the 49ers in the red zone and led to a two-yard touchdown pass from Brock Purdy to Mike Evans four plays later. Green picked off Darnold again on a deep pass attempt to Elijah Arroyo on Seattle's second offensive play of the third quarter, though the 49ers did not end up scoring on the ensuing drive. It was the first multi-interception game of Green's career, and the 2024 second-rounder is now up to three picks through five regular-season games after logging only one through his first two seasons. He's up to 22 tackles (14 solo) and five pass defenses heading into Week 6 against the Commanders on Monday, Oct. 19.
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49ers' Upton Stout: Ready for Week 5
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Stout (shoulder) is active for Sunday's game against the Seahawks, Brooke Evans of the 49ers' official site reports.
Stout missed Friday's practice session due to an AC joint sprain the cornerback suffered during the 49ers' Week 4 win over the Broncos. Despite missing the final practice of Week 5 prep, Stout was able to recover enough from the injury to suit up for Sunday's divisional matchup with the Seahawks.
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49ers' Mykel Williams: In line to make 2026 debut Sunday
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The 49ers activated Williams (knee) from the reserve/PUP list Saturday, and he no longer carries an injury designation into Sunday's NFC West tilt against the Seahawks.
Williams is set to play in his first game since he tore his ACL in early November of 2025. It wouldn't be surprising to see the 2025 first-rounder operate under a snap count against Seattle. Nevertheless, the return of Williams is a welcome one for the 49ers, especially with Nick Bosa set to miss a third consecutive game due to a calf injury.
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49ers' James Thompson: Won't play against Seattle
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Thompson (ankle) has been ruled out for Sunday's game against the Seahawks.
As expected, Thompson will miss a third consecutive game due to an ankle injury. He didn't practice once during Week 5 prep, so he'll need to return to the field to have a realistic shot of being available for Week 6 against the Commanders on Monday, Oct. 19. Naquan Jones and Sebastian Valdez will both see an uptick in rotational snaps at defensive tackle behind Osa Odighizuwa and Gracen Halton.
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49ers' Mykel Williams: Questionable with ACL injury
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Williams (knee) is listed as questionable ahead of Sunday's game against the Seahawks.
The 49ers opened Williams' 21-day practice window Wednesday. The defensive end was limited to start the week before upgrading to a full participant in Friday's practice. With a week of practice under his belt, there is a chance the team could move Williams back to the 53-man roster from the reserve/PUP list in time for Sunday's contest.
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49ers' Upton Stout: Questionable for Sunday
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Stout (shoulder) is listed as questionable ahead of Sunday's game against the Seahawks.
Stout is day-to-day with an AC joint sprain. The cornerback practiced in a limited capacity Thursday while missing the 49ers' Wednesday and Friday sessions. Stout has an outside chance to play in Sunday's contest but with one limited practice session during the middle of the week, it is unlikely. If Stout does not play, Ephesians Prysock, Siran Neal or Jack Jones will likely start at slot cornerback against the Seahawks.
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49ers' Nick Bosa: Won't return Week 5
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Bosa (calf) has been ruled out ahead of Sunday's game against the Seahawks.
Bosa is hoping to suit up for the 49ers' Week 6 game against the Commanders, Cam Inman of The San Jose Mercury News reports. With the star defensive end still sidelined for the Week 5 divisional showdown, Ogbo Okoronkwo should start against the Seahawks on Sunday.
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49ers' Upton Stout: Viewed as day-to-day
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San Francisco head coach Kyle Shanahan said Monday that Stout is day-to-day with an AC joint sprain in his shoulder, David Lombardi of SFStandard.com reports.
Stout missed time during the fourth quarter of Sunday's 24-14 win over the Broncos due to the shoulder issue, but he was able to check back into the game after receiving treatment. Though his practice participation could be affected by the injury in Week 5, the expectation is that he'll be ready to play this coming Sunday in Seattle.
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49ers' Fred Warner: Solid in win
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Warner recorded seven tackles (three solo) and two passes defensed during Sunday's 24-14 win versus the Broncos.
Warner took a step back in the tackle department compared to his 17-tackle performance versus the Cardinals in Week 3, but he continued to look sharp in coverage in Week 4. He profiles as an elite IDP option in most formats going into a Week 5 tilt at Seattle.
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49ers' Dre Greenlaw: San Fran's leading tackler in win
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Greenlaw recorded 12 tackles (seven solo) and forced a fumble during Sunday's 24-14 win versus the Broncos.
Greenlaw looked like he was out for revenge against the team that cut him back in March, managing his best tackle total since the 2023 season. He's worth IDP consideration in most formats going into a Week 5 matchup against a run-oriented Seahawks offense.
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49ers' James Thompson: Expects to be out again at Seattle
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Coach Kyle Shanahan said Monday that Thompson (ankle) is not expected back for Week 5, Cam Inman of The San Jose Mercury News reports.
Thompson has already missed the 49ers' last two games with an ankle injury he picked up in Week 2 versus the Dolphins, and it seems like he's trending towards missing another contest come Sunday. In that case, Sebastian Valdez would be a candidate for increased snaps on the defensive line.
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49ers' Nick Bosa: Likely won't suit up for Week 5
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Bosa (calf) is unlikely to be ready for the 49ers' Week 5 matchup against the Seahawks, Cam Inman of The San Jose Mercury News reports.
Bosa remains week-to-week with a calf injury and is not expected to be ready for Sunday's divisional matchup. The star defensive end will likely once again ride the bench as Ogbo Okoronkwo starts across from Keion White against the Super Bowl 60 champs.
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49ers' Marques Sigle: Set to miss multiple weeks
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Sigle is expected to miss multiple weeks due to a high-ankle injury that he sustained during the 49ers' 24-14 win over the Broncos on Sunday, Matt Barrows of The Athletic reports.
Sigle sustained the injury late in the first quarter while on kickoff coverage and was not on the field for the 49ers' final defensive drive of the game. It wouldn't be surprising if the second-year pro goes on injured reserve, and in his absence, Malik Mustapha figures to be the next man up at safety next to Ji'Ayir Brown, with Siran Neal and Ashtyn Davis both providing depth at the position.
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49ers' Marques Sigle: Dealing with ankle injury
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Sigle suffered an ankle injury during Sunday's 24-14 win over the Broncos.
Sigle finished the game having recorded six total tackles (four solo), but he picked up an ankle injury along the way. The safety's status at the team's first practice of the week Wednesday will shed more light on his availability for Week 5 against the Seahawks.
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49ers' Upton Stout: Returns against Denver
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Stout (shoulder) returned to Sunday's game against the Broncos, Nick Wagoner of ESPN.com reports.
Stout briefly missed time in the fourth quarter with the shoulder issue. He has six tackles (four solo) in Sunday's game against Denver.
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49ers' Upton Stout: Dealing with shoulder injury
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Stout (shoulder) is questionable to return to Sunday's game against the Broncos, Nick Wagoner of ESPN.com reports.
With Stout injured, Jack Jones is the only other healthy cornerback on the roster behind Renardo Gren and Deommodore Lenoir. Prior to exiting Sunday, Stout recorded six tackles (four solo). He handles slot cornerback duties for the Niners.
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49ers' Dre Greenlaw: Cleared to play against Denver
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Greenlaw (quadriceps) is active for Sunday's game against the Broncos.
Greenlaw has been officially cleared by medical staff to play Sunday, with the veteran linebacker being limited in practice by a quadriceps injury. He'll start alongside Fred Warner and Jaden Dugger at linebacker while Luke Gifford and Garret Wallow provide depth at the position.
