49ers' Mykel Williams: In line to make 2026 debut Sunday
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The 49ers activated Williams (knee) from the reserve/PUP list Saturday, and he no longer carries an injury designation into Sunday's NFC West tilt against the Seahawks.
Williams is set to play in his first game since he tore his ACL in early November of 2025. It wouldn't be surprising to see the 2025 first-rounder operate under a snap count against Seattle. Nevertheless, the return of Williams is a welcome one for the 49ers, especially with Nick Bosa set to miss a third consecutive game due to a calf injury.
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49ers' James Thompson: Won't play against Seattle
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Thompson (ankle) has been ruled out for Sunday's game against the Seahawks.
As expected, Thompson will miss a third consecutive game due to an ankle injury. He didn't practice once during Week 5 prep, so he'll need to return to the field to have a realistic shot of being available for Week 6 against the Commanders on Monday, Oct. 19. Naquan Jones and Sebastian Valdez will both see an uptick in rotational snaps at defensive tackle behind Osa Odighizuwa and Gracen Halton.
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49ers' Mykel Williams: Questionable with ACL injury
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Williams (knee) is listed as questionable ahead of Sunday's game against the Seahawks.
The 49ers opened Williams' 21-day practice window Wednesday. The defensive end was limited to start the week before upgrading to a full participant in Friday's practice. With a week of practice under his belt, there is a chance the team could move Williams back to the 53-man roster from the reserve/PUP list in time for Sunday's contest.
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49ers' Upton Stout: Questionable for Sunday
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Stout (shoulder) is listed as questionable ahead of Sunday's game against the Seahawks.
Stout is day-to-day with an AC joint sprain. The cornerback practiced in a limited capacity Thursday while missing the 49ers' Wednesday and Friday sessions. Stout has an outside chance to play in Sunday's contest but with one limited practice session during the middle of the week, it is unlikely. If Stout does not play, Ephesians Prysock, Siran Neal or Jack Jones will likely start at slot cornerback against the Seahawks.
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49ers' Nick Bosa: Won't return Week 5
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Bosa (calf) has been ruled out ahead of Sunday's game against the Seahawks.
Bosa is hoping to suit up for the 49ers' Week 6 game against the Commanders, Cam Inman of The San Jose Mercury News reports. With the star defensive end still sidelined for the Week 5 divisional showdown, Ogbo Okoronkwo should start against the Seahawks on Sunday.
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49ers' Upton Stout: Viewed as day-to-day
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San Francisco head coach Kyle Shanahan said Monday that Stout is day-to-day with an AC joint sprain in his shoulder, David Lombardi of SFStandard.com reports.
Stout missed time during the fourth quarter of Sunday's 24-14 win over the Broncos due to the shoulder issue, but he was able to check back into the game after receiving treatment. Though his practice participation could be affected by the injury in Week 5, the expectation is that he'll be ready to play this coming Sunday in Seattle.
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49ers' Fred Warner: Solid in win
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Warner recorded seven tackles (three solo) and two passes defensed during Sunday's 24-14 win versus the Broncos.
Warner took a step back in the tackle department compared to his 17-tackle performance versus the Cardinals in Week 3, but he continued to look sharp in coverage in Week 4. He profiles as an elite IDP option in most formats going into a Week 5 tilt at Seattle.
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49ers' Dre Greenlaw: San Fran's leading tackler in win
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Greenlaw recorded 12 tackles (seven solo) and forced a fumble during Sunday's 24-14 win versus the Broncos.
Greenlaw looked like he was out for revenge against the team that cut him back in March, managing his best tackle total since the 2023 season. He's worth IDP consideration in most formats going into a Week 5 matchup against a run-oriented Seahawks offense.
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49ers' James Thompson: Expects to be out again at Seattle
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Coach Kyle Shanahan said Monday that Thompson (ankle) is not expected back for Week 5, Cam Inman of The San Jose Mercury News reports.
Thompson has already missed the 49ers' last two games with an ankle injury he picked up in Week 2 versus the Dolphins, and it seems like he's trending towards missing another contest come Sunday. In that case, Sebastian Valdez would be a candidate for increased snaps on the defensive line.
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49ers' Nick Bosa: Likely won't suit up for Week 5
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Bosa (calf) is unlikely to be ready for the 49ers' Week 5 matchup against the Seahawks, Cam Inman of The San Jose Mercury News reports.
Bosa remains week-to-week with a calf injury and is not expected to be ready for Sunday's divisional matchup. The star defensive end will likely once again ride the bench as Ogbo Okoronkwo starts across from Keion White against the Super Bowl 60 champs.
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49ers' Marques Sigle: Set to miss multiple weeks
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Sigle is expected to miss multiple weeks due to a high-ankle injury that he sustained during the 49ers' 24-14 win over the Broncos on Sunday, Matt Barrows of The Athletic reports.
Sigle sustained the injury late in the first quarter while on kickoff coverage and was not on the field for the 49ers' final defensive drive of the game. It wouldn't be surprising if the second-year pro goes on injured reserve, and in his absence, Malik Mustapha figures to be the next man up at safety next to Ji'Ayir Brown, with Siran Neal and Ashtyn Davis both providing depth at the position.
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49ers' Marques Sigle: Dealing with ankle injury
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Sigle suffered an ankle injury during Sunday's 24-14 win over the Broncos.
Sigle finished the game having recorded six total tackles (four solo), but he picked up an ankle injury along the way. The safety's status at the team's first practice of the week Wednesday will shed more light on his availability for Week 5 against the Seahawks.
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49ers' Upton Stout: Returns against Denver
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Stout (shoulder) returned to Sunday's game against the Broncos, Nick Wagoner of ESPN.com reports.
Stout briefly missed time in the fourth quarter with the shoulder issue. He has six tackles (four solo) in Sunday's game against Denver.
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49ers' Upton Stout: Dealing with shoulder injury
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Stout (shoulder) is questionable to return to Sunday's game against the Broncos, Nick Wagoner of ESPN.com reports.
With Stout injured, Jack Jones is the only other healthy cornerback on the roster behind Renardo Gren and Deommodore Lenoir. Prior to exiting Sunday, Stout recorded six tackles (four solo). He handles slot cornerback duties for the Niners.
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49ers' Dre Greenlaw: Cleared to play against Denver
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Greenlaw (quadriceps) is active for Sunday's game against the Broncos.
Greenlaw has been officially cleared by medical staff to play Sunday, with the veteran linebacker being limited in practice by a quadriceps injury. He'll start alongside Fred Warner and Jaden Dugger at linebacker while Luke Gifford and Garret Wallow provide depth at the position.
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49ers' Dre Greenlaw: Trending toward playing vs. Denver
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Greenlaw (quadriceps) is expected to play against the Broncos on Sunday, Jeremy Fowler of ESPN.com reports.
Greenlaw drew the questionable tag for Week 4 after logging a DNP-DNP-LP practice log. The veteran linebacker is nursing a quadriceps injury, but it looks like he'll suit up for Sunday's home tilt. Greenlaw has 22 tackles (nine solo) through the first three games of the regular season.
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49ers' Romello Height: Cleared to play versus Denver
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Height (hand) does not carry an injury designation for Sunday's game against Denver.
Height didn't play in Week 3 against Arizona and practiced in a limited capacity throughout the week. However, he is cleared to suit up for Sunday's game versus the Broncos. The 25-year-old has appeared in two games thus far during the 2026 campaign, amassing one total tackle (one solo) and 1.0 sack.
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49ers' Dre Greenlaw: Misses another practice
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Greenlaw (quadriceps) did not practice Thursday, Nick Wagoner of ESPN.com reports.
Greenlaw suffered a quadriceps injury late in the victory over Arizona on Sunday. Since then, he has missed two consecutive practices, so he will have another opportunity Friday to make some progress. If Greenlaw is unavailable versus Denver in Week 4, Garret Wallow may be needed to fill the void in the lineup.
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49ers' Gracen Halton: Fades injury report
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Halton (ankle) was not listed on Wednesday's practice report, Vic Tafur of The Athletic reports.
Halton did not return to the 49ers' Week 3 win over the Cardinals due to an ankle injury. However, his absence from Wednesday's injury report indicates that his ankle is fine, and the rookie fourth-rounder should be available for Sunday's home game against the Broncos. Halton has eight tackles (five solo) and one pass defense through the first three games of the regular season.
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49ers' Dre Greenlaw: DNP to open Week 4 prep
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Greenlaw (quadriceps) didn't practice Wednesday, Vic Tafur of The Athletic reports.
Greenlaw injured his quad during the fourth quarter of the 49ers' 36-30 win over the Cardinals in Week 3, when he logged eight tackles (three solo). The veteran linebacker will need to return to practice in at least a limited capacity over the coming days to have a realistic chance of playing against the Broncos on Sunday. If Greenlaw is unable to play, then Garret Wallow would likely start alongside Fred Warner and Jaden Dugger at linebacker.
