Naomi Osaka has won 18 straight matches and now faces Taiwan's Su-Wei Hsieh in the 2021 Australian Open quarterfinals at 8:30 p.m. ET on Monday. Osaka won this event in 2019 for her third Grand Slam title and boasts a strong all-around game that propelled her to the world's top spot that season. She is the defending U.S. Open champion and showcased her tenacity in a victory against former No. 1 Garbine Muguruza in the fourth round. Hsieh is making her major quarterfinals debut but has found success against top competition in recent years.

The latest Osaka vs. Hsieh odds from William Hill Sportsbook list Osaka as the -900 favorite (risk $900 to win $100) to win the match outright. Hsieh is a +550 underdog (risk $100 to win $550). There are a variety of other Osaka vs. Hsieh picks you can make, including a -250 play on Osaka to win it in two sets and +1400 on Hsieh to take it in three. Before making any 2021 Australian Open women's quarterfinals picks, you need to check out the 2021 Australian Open predictions from famed tennis handicapper Gavin Mair.

Mair is the international women's tennis expert who called unseeded Jelena Ostapenko (80-1) winning the 2017 French Open, Naomi Osaka (32-1) winning the 2018 U.S. Open, Bianca Andreescu (20-1) winning the 2019 U.S. Open, plus many other spot-on calls.

Before the women's singles final in the most recent Grand Slam, the French Open, Mair picked Iga Swiatek to win (-163) and win in straight sets (+140), and he was right on both counts as the 19-year-old beat Simona Halep for her first title.

Now, Mair has been digging deep into the latest Australian Open 2021 odds and has released his coveted best bets. He's sharing all his picks and analysis at SportsLine.

Naomi Osaka vs. Su-Wei Hsieh preview

Mair knows Osaka has one of the sport's top all-around games, while her 125-mph serve and aggressiveness could overwhelm the veteran Hsieh. The 23-year-old American escaped an upset against Muguruza by fighting off two match points and winning the last four games. Muguruza had been broken only once in this Australian Open, but Osaka broke her five times.

Osaka has faced Hsieh five times, winning four of those matchups, including all three on hard courts. She will use her power to neutralize the Taiwanese player's reliance on slices and drop shots and try to settle into a baseline game. She is familiar with Hsieh's approach and knows she needs to set the tone early to avoid a long match like their previous showdowns. 

Hsieh is the oldest player to make her quarterfinal major debut and plays an unusual style that includes two-handed shots off both sides. This approach could fluster the third-seeded Osaka, who has beaten Hsieh four times in five tries, but only once in two sets. "I'm not really looking forward to it," Osaka told reporters of the matchup. "She's gonna be really tough."

Hsieh took down Marketa Vondrousova in her fourth-round match, and her crafty style led Vondrousova into 31 unforced errors. Hsieh also beat 2019 U.S. Open champion Bianca Andreescu in the second round, and she has been a late bloomer. Hsieh hadn't won a match against a top-10 opponent until 2017 but has seven wins against such players since then.

How to make Osaka vs. Hsieh picks

Is Osaka's all-around talent enough to overcome the crafty Hsieh? The tennis guru has released confident picks on the outright winner, as well as advice on game handicap and set betting. Be sure to see Mair's picks and analysis before making your Australian Open 2021 picks for the women's quarterfinals.

Who wins Naomi Osaka vs. Su-Wei Hsieh? And what pick could lead to a big return? Visit SportsLine now to see Gavin Mair's best bets for Osaka vs. Hsieh, all from the acclaimed expert who hit it big in the last grand slam women's final, and find out.