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The ninth-seeded Creighton Bluejays will try to make a statement on Saturday when they take on the No. 1 seed Kansas Jayhawks in the second round of the 2022 NCAA Tournament. The Bluejays needed overtime to secure their victory over San Diego State, while Kansas dominated the Texas Southern Tigers, 83-56. The Bluejays enter Saturday's showdown having won 10 of their last 13 games. Kansas, meanwhile, has won each of its six contests.

Tipoff for this one is at 2:40 p.m. ET in Fort Worth, Texas. The Jayhawks are 11.5-point favorites in the latest Kansas vs. Creighton odds from Caesars Sportsbook, while the over-under for total points scored is 139.5. Before making any Creighton vs. Kansas picks, be sure to see the college basketball predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Kansas vs. Creighton and revealed its coveted picks and predictions for the NCAA Tournament 2022. You can head to SportsLine to see the picks. Here are several college basketball odds and trends for Creighton vs. Kansas:

  • Kansas vs. Creighton spread: Kansas -11.5
  • Kansas vs. Creighton over-under: 139.5 points
  • Kansas vs. Creighton money line: Kansas -700, Creighton +475
  • KAN: The Jayhawks are 5-0 against the spread in their last five games
  • CRE: The Bluejays are 5-1 ATS in their last six games played in March

Why Kansas can cover

The Jayhawks are playing some inspired basketball down the stretch. Kansas has won each of its last six games by 14 points on average. The Jayhawks are led offensively by Ochai Agbaji, who's averaging 19.4 points per game. The senior guard has scored 20 or more points 18 times this season.

Agbaji is lethal from behind the arc, knocking down 40.1 percent of his shots from 3-point range. As a team, Kansas ranks 16th in the country in field-goal percentage (48.16). In addition, the Jayhawks have covered the spread in each of their last five outings. 

Why Creighton can cover

The underdog role seems to suit the Bluejays, who've won four of their last five games when playing as the underdog. Creighton secured a dominant 85-58 victory over the Providence Friars on March 11 as three-point underdogs. Several other betting trends work in Creighton's favor in this one.

The Bluejays were 13-6 against the spread when playing away from home this season and 13-5 ATS when they were underdogs. They're missing a couple key pieces with Ryan Kalkbrenner (knee) and Ryan Nembhard (wrist) out, so they'll be leaning heavily on forward Ryan Hawkins (13.8 ppg) and guard Alex O'Connell (11.6 ppg).

How to make Creighton vs. Kansas picks

SportsLine's model is leaning over on the point total, projecting the teams to combine for 143 points. The model also says one side of the spread hits 70 percent of the time. You can only see the model's pick at SportsLine.

So who wins Kansas vs. Creighton? And which side of the spread hits 70 percent of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.