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Ranked foes meet in Big East Conference action on Wednesday when the top-ranked Connecticut Huskies entertain the 18th-ranked Creighton Bluejays in Storrs, Conn. The Bluejays (13-4, 4-2 Big East), who are looking to win their fifth game in a row, are 4-1 on the road this year. The Huskies (15-2, 5-1 Big East), who look to extend their win streak to six games, are 9-0 on their home court this season. Creighton, however, holds a 6-1 edge in the all-time series. UConn center Donovan Clingan (foot) is questionable.

The game from Gampel Pavilion starts at 7 p.m. ET. Creighton is averaging 76.4 points per game, 64th-best in the country, while UConn averages 78.6, tied for 30th nationally. The Huskies are 6.5-point favorites in the latest Creighton vs. UConn odds from SportsLine consensus, while the over/under for total points scored is 145.5. Before making any UConn vs. Creighton picks, be sure to see the college basketball predictions from SportsLine's proven model.

The model simulates every Division I college basketball game 10,000 times. It enters Week 11 of the 2023-24 season on a 110-73 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 15-5 start on top-rated spread picks this season. Anyone following has seen huge returns.

The model has set its sights on UConn vs. Creighton. You can head to SportsLine now to see the picks. Now here are the latest betting trends and lines for Creighton vs. UConn:

  • UConn vs. Creighton spread: UConn -6.5
  • UConn vs. Creighton over/under: 145.5 points
  • UConn vs. Creighton money line: UConn -274, Creighton +221
  • CREI: The Bluejays have hit the first-half money line in 30 of their last 36 games (+20.55 units)
  • UCONN: The Huskies have won 15 of their last 17 games (+12.10 units on ML)
  • UConn vs. Creighton picks: See picks at SportsLine

Why UConn can cover

Senior guard Cam Spencer is a threat from long distance and is in the top 25 among active players in 3-point percentage, averaging 46.8% from long range. He has 230 career 3-pointers and is connecting on 41.7% over his five-year career. Spencer has scored 20 points or more four times this season, including in the 80-67 win over Georgetown on Sunday. He also poured in 20 points in an 85-56 win over DePaul on Jan. 2.

Senior guard Tristen Newton has registered three double-doubles and one triple-double this season. In a 90-60 win over Manhattan on Nov. 24, Newton scored 15 points, while grabbing 10 rebounds and adding 13 assists. He scored a season-high 31 points in a 69-65 loss to fifth-ranked Kansas on Dec. 1. His last double-double came in an 80-75 win over Xavier on Jan. 10, when he scored 16 points, while dishing out 11 assists. See who to back at SportsLine.

Why Creighton can cover

The Bluejays have three players averaging 15.9 points per game or better. Fifth-year senior Baylor Scheierman leads the way, averaging 18 points, 8.3 rebounds and 3.9 assists per game. In 17 starts, he has registered six double-doubles, including a 17-point and 12-rebound effort in the win over St. John's on Saturday. He scored 18 points and pulled down 12 boards in a 77-60 win over Georgetown on Jan. 2.

Another weapon on offense is junior guard Trey Alexander. In 17 games, all starts, he is averaging 16.3 points, 6.1 rebounds, 4.5 assists and 1.1 steals in a team-high 34.9 minutes. He has scored 20 or more points in eight games this season. He is one of 20 players named to the Jerry West Shooting Guard of the Year Preseason Watch List. See who to back at SportsLine.

How to make Creighton vs. UConn picks

The model has simulated this matchup 10,000 times and the results are in. The model is leaning Over the total, and it also says one side of the spread hits in well over 50% of simulations. You can only see the picks at SportsLine.

So who wins UConn vs. Creighton, and which side of the spread hits well over 50% of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that is on a 110-73 roll on its top-ranked college basketball picks, and find out.