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A Pac-12 battle is on tap as the Arizona State Sun Devils and the USC Trojans will face off at 10:30 p.m. ET on Saturday, Nov. 6 at Sun Devil Stadium, Frank Kush Field. ASU is 5-3 overall and 4-1 at home, while USC is 4-4 overall and 2-1 on the road. USC leads the all-time series 23-13. Both teams are 3-5 against the spread in 2021.

Arizona State is favored by eight points in the latest Arizona State vs. USC odds from Caesars Sportsbook, and the over-under is set at 59.5. Before locking in any USC vs. Arizona State picks, you need to see the college football predictions and betting advice from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Arizona State vs. USC and just released its coveted college football picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for Arizona State vs. USC:

  • Arizona State vs. USC spread: Arizona State -8
  • Arizona State vs. USC over-under: 60 points

What you need to know about Arizona State

The Sun Devils entered their contest against the Washington State Cougars on Saturday without any home losses -- but there's a first time for everything. ASU came up short against Washington State, falling 34-21. The Sun Devils were down 28-7 at the end of the third quarter, which was just too much to recover from. No one had a standout game offensively for ASU, but they got scores from a handful of players including RB DeaMonte Trayanum, WR LV Bunkley-Shelton, and WR Andre Johnson.

After a hot start to the season, the Arizona State defense has given up 69 points in its last two games (both losses). To cover this spread, the Sun Devils' defense will need to regain its early season form. Arizona State can secure bowl eligibility with a win on Saturday. 

What you need to know about USC

Meanwhile, the Trojans beat the Arizona Wildcats 41-34 on Saturday. The team accrued 35 points in the first half and coasted on those for the victory. RB Keaontay Ingram continued his habit of dropping crazy stat lines, rushing for one TD and 186 yards on 26 carries.

USC has been arguably the most inconsistent team in the Pac-12 in 2021. Depending on which team shows up, you may see a Trojans squad that looks primed to contend for a conference title, or you may see a group that looks incredibly uninspired. USC will be without star wide receiver Drake London (ankle) for the rest of the season.

How to make USC vs. Arizona State picks

The model has simulated Arizona State vs. USC 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the model's USC vs. Arizona St. pick at SportsLine.

So who wins Arizona St. vs. USC? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.