Isbel is out of the lineup for the second game of Monday's doubleheader with the Guardians.
The lefty-hitting Isbel drew the start in the Royals' 4-3 win earlier in the day while the Guardians opted for a bullpen game, but he'll head to the bench for Game 2 with southpaw Logan Allen toeing the rubber for Cleveland. Garrett Hampson will pick up a start in center field in place of Isbel, who went 1-for-4 in the first contest of the day.