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The 49ers designated Burford (knee) to return to practice on Wednesday.

Burford hurt his knee in Week 2 against New Orleans and subsequently landed on IR. He's since missed the required four games and is eligible to be activated when the team deems him ready. Burford logged a limited practice session Wednesday, per Vic Tafur of The Athletic, and it's unclear if he'll be back in action this Sunday versus Houston.

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