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Players are generally the healthiest at the beginning of the season, but there are still multiple Fantasy football injuries to monitor during the Week 1 NFL schedule. Packers wide receiver Christian Watson (hamstring) is among the notable players who have already been ruled out. Teammate Romeo Doubs is second on Green Bay's wide receiver depth chart, but he is questionable for Sunday's game with a hamstring injury of his own. Those injuries and others will force some owners to adjust their Week 1 Fantasy football strategy.

Packers rookie wide receiver Jayden Reed could fly under the radar due to injuries ahead of him on the Packers depth chart. Reed had a strong training camp and is going to have an expanded role in Week 1, making him a flex option in the Week 1 Fantasy football rankings. Before you lock in your lineups, be sure to check out the Week 1 Fantasy football projections and NFL injury updates from the advanced computer model at SportsLine.

With the SportsLine Projection Model, you can get live-updated projections that can help you inform your lineup decisions in the event of any Fantasy football injuries. SportsLine's model beat human experts for the past several seasons, especially when there were big differences in ranking. It updates multiple times daily to give you the most up-to-date information as the latest NFL injury news breaks.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football projections for Week 1 of the 2023 NFL season. Head to SportsLine now to see the Week 1 Fantasy football projections and stay up to date with the latest NFL injuries.

Top Week 1 Fantasy football injury projections

One Fantasy football injury that the model can help you deal with: Rams wide receiver Cooper Kupp. The No. 1 wide receiver in Los Angeles is on injured reserve due to his hamstring, which will knock him out for at least four games. Kupp recently suffered a setback with his hamstring injury after being considered day-to-day heading into September.

He caught 75 passes for 812 yards and six touchdowns on 98 targets last season, missing eight games due to a high-ankle sprain. Kupp was coming off a brilliant 2021 campaign, leading the league in receptions, receiving yards and receiving touchdowns, helping Los Angeles win Super Bowl LVI over Cincinnati. His ceiling is among the highest in the NFL, so many Fantasy owners will stash him on an injured list.

Van Jefferson is expected to be the biggest beneficiary of Kupp's absence, as he can now serve as quarterback Matthew Stafford's top target. Jefferson had 50 receptions for 802 yards and six touchdowns last season and is sitting ahead of Tutu Atwell, Ben Skowronek and Puka Nacua on the Rams depth chart. However, SportsLine's model has Jefferson finishing with just 3.1 receptions, 48 yards and 0.24 touchdowns against Seattle on Sunday in its latest simulations, so you might want to look elsewhere for a more consistent replacement. For more start/sit Fantasy football advice, be sure to check out the rest of the Week 1 Fantasy football projections.

How to optimize your Week 1 Fantasy football lineups

The model is also calling for a surprising quarterback you aren't even thinking about to finish in the top five of its Week 1 Fantasy football rankings. This pick could be the difference between winning big and going home with nothing. See the Week 1 Fantasy football stat projections here.

So who should you start and sit this week? And how should you handle high-profile Fantasy football injuries like McLaurin and Kittle? Visit SportsLine now to get Week 1 Fantasy football projections for every position, with live updates to account for all the latest NFL injury news, all from the model that has outperformed experts big-time.