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Jack Nicklaus designed Muirfield Village Golf Club in 1974 and he founded the Memorial Tournament in 1976. In the 46 years since, the event has become one of the most prestigious on the PGA Tour and the 2022 Memorial Tournament will feature a loaded 120-player field vying for a three-year exemption and a $2.16 million winner's purse. Jon Rahm was well on his way to a victory last year with a six-shot lead after three rounds but a positive COVID-19 test forced him to withdraw.

Rahm earned redemption just a few weeks later with a win at the 2021 U.S. Open and he's listed as the 9-1 favorite in the 2022 Memorial Tournament odds from Caesars Sportsbook. Patrick Cantlay went on to win last year's Memorial Tournament in his absence, his second win at Muirfield Village, and he's listed at 14-1 in this week's PGA Tour odds. Before locking in any Memorial Tournament 2022 picks of your own, be sure to check out the PGA predictions and betting advice from SportsLine golf expert Mike McClure.

SportsLine's proprietary model, built by DFS pro Mike McClure, has been red-hot since the PGA Tour resumed in June of 2020. In fact, it's up over $9,500 on its best bets since that point, nailing tournament after tournament.

At the 2022 Masters, McClure's model was all over Scottie Scheffler's first career major championship victory heading into the weekend. In addition, McClure's best bets included Collin Morikawa winning outright at the 2021 Open Championship, even though he was listed as a massive 40-1 long shot. The model was also all over Jon Rahm's (10-1) first career major championship victory at the 2021 U.S. Open. Rahm was two strokes off the lead heading into the weekend, but the model still projected him as the winner. 

This same model has also nailed a whopping eight majors entering the weekend. Anyone who has followed it has seen massive returns.

Now, McClure has set his sights on the 2022 Memorial Tournament field and just revealed his top PGA prop bets. You can head to SportsLine now to see McClure's 2022 Memorial Tournament prop picks, sleepers, head-to-head matchups, best bets, and his top one and done pick.

Memorial Tournament prop bets

McClure's 2022 Charles Schwab Challenge prop picks include Joaquin Niemann finishing inside the top 20 at +180 odds. Niemann is currently No. 18 in the Official World Golf Ranking and he's already had four top-10 finishes during the 2021-22 PGA Tour season. That includes a win at the 2022 Genesis Invitational, another 120-player field with enhanced prize money hosted by a golf legend (Tiger Woods).

Niemann has made the cut in his last six PGA Tour starts and this will be his fifth start in the Memorial Tournament so he should know his way around Muirfield Village pretty well at this point. 

He finishedTt-6th in this event in 2018 and his combination of off-the-tee accuracy and short-game prowess should make him a factor again this week.

Memorial Tournament one-and-done picks

One of McClure's favorite 2022 Memorial Tournament one-and-done picks this week is Viktor Hovland. The 24-year-old Norwegian turned professional after a t-12th finish that made him the low amateur at the 2019 U.S. Open and has already collected six worldwide wins, including three on the PGA Tour. He's made the cut both times that he's played the Memorial Tournament and he has a game that seems well suited for Muirfield Village. The No. 7 player in the world is one of the best iron players in the world and Nicklaus' design definitely puts an emphasis on approach accuracy.

Memorial Tournament head-to-head matchup picks

One of McClure's favorite bets this week is Seamus Power (-120) over Marc Leishman in a head-to-head golf betting matchup. A little over a year ago, Power was ranked outside the top 400 in the world but a win at the Barbasol Championship and eight other top-10 finishes in the last 14 months has vaulted him all the way to No. 40 in the Official World Golf Ranking.

Power has played well in some marquee events of late, earning top 10 finishes at the PGA Championship, the WGC Dell-Technologies Match Play, AT&T Pebble Beach Pro-Am and the Sony Open in 2022. Meanwhile, Leishman has finished 30th or worse in each of his last seven worldwide starts with two missed cuts and two finishes outside the top 50. Expect Power to be motivated in his first Memorial Tournament invitation and to outplay Leishman over four rounds.

Find more Memorial Tournament picks, sleepers

McClure has also locked in a slew of other prop bets for the 2022 Memorial Tournament, including a long shot listed at 50-1 to win it all. Anyone who backs one of his 2022 Memorial Tournament sleepers could hit it big. You can only see his Memorial Tournament best bets at SportsLine.

So what 2022 Memorial Tournament prop picks should you target? And which massive long shot has a chance to stun the golfing world? Visit SportsLine to see McClure's 2022 Memorial Tournament best bets, all from the expert who's up over $9,500 since the restart, and find out.

2022 Memorial Tournament odds, field, top contenders

Jon Rahm 9-1
Rory McIlroy 10-1
Patrick Cantlay 14-1
Jordan Spieth 18-1
Cameron Smith 18-1
Collin Morikawa 18-1
Xander Schauffele 20-1
Viktor Hovland 22-1
Shane Lowry 22-1
Matt Fitzpatrick 25-1
Hideki Matsuyama 25-1
Will Zalatoris 28-1
Joaquin Niemann 35-1
Max Homa 35-1
Cameron Young 35-1
Sungjae Im 35-1
Davis Riley 40-1
Daniel Berger 40-1
Mito Pereira 45-1
Keegan Bradley 50-1
Abraham Ancer 50-1
Corey Conners 50-1
Patrick Reed 50-1
Seamus Power 55-1
Billy Horschel 60-1
Jason Day 60-1
Bryson DeChambeau 60-1
Adam Scott 60-1
Chris Kirk 60-1
Marc Leishman 60-1
Matt Kuchar 65-1
Aaron Wise 65-1
Gary Woodland 65-1
Alex Noren 65-1
Tom Hoge 80-1
Si-Woo Kim 80-1
Ryan Palmer 80-1
Rickie Fowler 80-1
Brian Harman 80-1
C.T. Pan 100-1
Lanto Griffin 100-1
Harris English 100-1
Keith Mitchell 100-1
Cameron Tringale 100-1
Jhonattan Vegas 100-1
Cameron Champ 100-1
Kyoung-Hoon Lee 100-1
Cam Davis 100-1
Adam Hadwin 100-1
Stewart Cink 100-1
Sepp Straka 100-1
Anirban Lahiri 125-1
Troy Merritt 125-1
Russell Knox 125-1
Kevin Streelman 125-1
Scott Stallings 125-1
Matt Jones 125-1
Luke List 125-1
Lucas Herbert 150-1
Denny McCarthy 150-1
Doug Ghim 150-1
Pat Perez 150-1
Brendan Steele 150-1
Charles Howell 150-1
Aaron Rai 150-1
Joel Dahmen 150-1
Erik Van Rooyen 150-1
Adam Long 150-1
Mackenzie Hughes 150-1
Patton Kizzire 150-1
Matthew NeSmith 150-1
Matthew Wolff 150-1
J.T. Poston 175-1
Lucas Glover 175-1
Emiliano Grillo 200-1
Patrick Rodgers 200-1
Ryan Moore 200-1
Andrew Putnam 200-1
Beau Hossler 200-1
Alex Smalley 200-1
Danny Willett 200-1
Kurt Kitayama 200-1
Francesco Molinari 200-1
Sahith Theegala 200-1
Martin Laird 250-1
David Lipsky 250-1
Nate Lashley 250-1
Brandt Snedeker 250-1
Peter Malnati 250-1
Chad Ramey 250-1
Charley Hoffman 300-1
Danny Lee 300-1
Harry Higgs 300-1
Adam Svensson 300-1
Luke Donald 300-1
Carlos Ortiz 300-1
Hudson Swafford 300-1
Taylor Moore 300-1
Wyndham Clark 300-1
Garrick Higgo 300-1
Rafa Cabrera Bello 300-1
Min Woo Lee 300-1
Brandon Wu 300-1
Adam Schenk 350-1
Justin Lower 400-1
Camilo Villegas 500-1
Curtis Luck 500-1
Bo Hoag 500-1
Robert Streb 500-1
David Lingmerth 500-1
Jediah Morgan 500-1
Chan Kim 500-1
John Pak 500-1
Ryan Brehm 500-1
William McGirt 500-1
Brandon Hagy 500-1
Jason Dufner 500-1
Nick Watney 500-1
Laird Shepherd 1000-1
James Piot 1000-1