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New York will play its eighth straight game against a divisional opponent to open the season when it travels to Baltimore on Friday night. The Yankees (4-3) won two out of three against Boston last weekend, but they had to settle for a four-game split against Toronto earlier this week. Baltimore has lost five of its first six games, including a 4-2 setback against Milwaukee on Wednesday. Lefty Jordan Montgomery (0-0, 8.10 ERA) is scheduled to start for New York, while righty Jordan Lyles (0-1, 9.00 ERA) is on the hill for Baltimore.

First pitch is set for 7:05 p.m. ET from Oriole Park at Camden Yards in Baltimore. New York is listed as the -210 favorite on the money line (risk $210 to win $100) in the latest Yankees vs. Orioles odds from Caesars Sportsbook, with the over-under set at nine runs. Before making any Orioles vs. Yankees picks, you need to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters Week 2 of the 2022 season on a 216-181 roll on top-rated MLB money-line picks that dates back to last season, returning over $900 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in on Yankees vs. Orioles, and just locked in its picks and MLB predictions. You can visit SportsLine now to see the model's picks. Here are the MLB odds and trends for Orioles vs. Yankees:

  • Yankees vs. Orioles money line: New York -210, Baltimore +180
  • Yankees vs. Orioles run-line: New York -1.5 (-130)
  • Yankees vs. Orioles over-under: 9 runs
  • NYY: Yankees are 3-4 ATS this season
  • BAL: Orioles are 3-3 ATS this season

Why you should back the Orioles

New York is being priced heavily in the betting market due to its strong offense. However, the bats have failed to show up so far this season, as the Yankees are averaging just 3.5 runs per game. They are also coming off a narrow win over Toronto on Thursday night, while Baltimore had the day off after wrapping up its series against Milwaukee.

The Orioles have been playing competitive games this year, with four of their five losses coming by one or two runs. Right fielder Anthony Santander is off to a red-hot start, entering Friday's game with an on-base percentage of .609. Lyles is 1-0 with a 3.12 ERA in two career appearances against the Yankees.

Why you should back the Yankees

New York took two out of three games against Boston last weekend before winning two of its final three games against Toronto earlier this week. The Yankees have recorded shutouts in two of their last three games, including a 3-0 win on Thursday night. Montgomery has dominated Baltimore during his career, owning a 3-1 record with a 3.08 ERA in 12 starts. 

The Yankees have one of the most dangerous lineups in the MLB, so they will be tough for Lyles to handle. Baltimore has also been unable to cash in on its scoring chances this year, going 5-for-55 with runners in scoring position. New York has won five of its last seven road games dating back to last season. 

How to make Yankees vs. Orioles picks

SportsLine's model is leaning over on the run total, as the simulation suggests the teams will combine for 9.4 runs. It also says one side of the money line has all the value. You can only get the model's pick at SportsLine. 

So who wins Orioles vs. Yankees? And which side of the money line has all the value? Visit SportsLine now to see which side to jump on, all from the advanced model that has crushed its top-rated MLB picks, and find out.