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Teams going in different directions will meet on Monday's NBA schedule as the Philadelphia 76ers host the Denver Nuggets. The Sixers (19-14) have won three in a row and are coming off 130-119 victory over New York. The Nuggets (23-12) have lost four of five, most recently losing 127-115 to Brooklyn. Joel Embiid (knee/ankle) is listed as probable, while Nikola Jokic (knee) and Jamal Murray (ankle) are among those out for Denver.

Tipoff is at 8:30 p.m. ET from Xfinity Mobile Arena in Philadelphia. Denver has won the last three meetings. Philly is a 15-point favorite in the latest 76ers vs. Nuggets odds per SportsLine consensus, while the over/under is 228.5 points. Before making any Nuggets vs. 76ers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

New users can also target the latest Underdog promo code, good for $75 in bonus entries when you play $5 with the promo code CBSSPORTS2 in select states.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 12 of the 2025-26 NBA season on a sizzling 33-15 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Nuggets vs. 76ers 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for 76ers vs. Nuggets: 

Nuggets vs. 76ers spread:    

76ers -15 at DraftKings Sportsbook

Nuggets vs. 76ers over/under:    

228.5 points

Nuggets vs. 76ers money line:    

76ers -971, Nuggets +634

Nuggets vs. 76ers picks:    

See picks at SportsLine

Nuggets vs. 76ers streaming:

Peacock

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How to make 76ers vs. Nuggets picks

After 10,000 simulations of Nuggets vs. Sixers, SportsLine's model is going Over on the total (228.5 points). No team has eclipsed the total as often as Denver, as the Over is 23-12 for the Nuggets this season, the highest clip in the NBA. The Over is 9-3 for the Nuggets over their last dozen road games, and it has hit in five of their last seven games overall. The latter also goes for Philly over its last seven, with the Over having a 5-2 record.

Philadelphia is a double-digit favorite, and the Sixers have frequently engaged in high-scoring games when favored by any amount. The Over is 11-6 when the Sixers are favored this season as 10 total players are projected to reach double-figures on Monday, with three of those scoring more than 24 points. The model is projecting the Over to hit with points to spare, as it forecasts 238 combined points. Thus, the Over is reached in over 60% of simulations.

The model also says one side of the spread hits almost 70% of the time. You can head to SportsLine to see the model's NBA picks. 

So who wins Sixers vs. Nuggets, and which side of the spread hits almost 70% of the time? Visit SportsLine now to see which side of the Nuggets vs. 76ers spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.