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The Jacksonville Jaguars and Cincinnati Bengals will duel it out on Thursday Night Football at Paul Brown Stadium. Jacksonville head coach Urban Meyer and quarterback Trevor Lawrence roll into town for the first time and try to emerge with their first NFL win. Bengals sophomore quarterback Joe Burrow and head coach Zac Taylor will try to keep the franchise rolling in the right direction and notch their third win of the season.

Kickoff from Paul Brown Stadium is at 8:20 p.m. ET. Cincinnati is a 7.5-point favorite in the latest Jaguars vs. Bengals odds from Caesars Sportsbook, while the Over-Under is 46. Before locking in your Jaguars vs. Bengals picks, make sure to check out the NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 4 of the 2021 season on an incredible 123-81 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Jaguars vs. Bengals 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Bengals vs. Jaguars:

  • Jaguars vs. Bengals spread: Bengals -7.5 
  • Jaguars vs. Bengals over-under: 46 points 
  • Jaguars vs. Bengals money line: Jacksonville +280, Cincinnati -350 
  • CIN: Bengals are 6-2 against the spread in their last eight home games 
  • JAX: Over is 5-0 in Jaguars' last five games in Week 4 

Why Bengals can cover

Burrow's rookie season was cut short to 10 games due to a torn ACL that ended his year. The second-year quarterback appears to be getting more confident, throwing a season-high three touchdowns against the Pittsburgh Steelers. Burrow has tossed at least two touchdowns in all three games this season.

The Jaguars' secondary has allowed 302.3 yards through the air and traded away one of its most talented cornerbacks. Jacksonville sent C.J. Henderson and a fifth-round pick to the Carolina Panthers for tight end Dan Arnold and a third-round pick. Burrow is averaging 216.3 passing yards per game, but should have the opportunity to throw for more. The former LSU product threw for over 300-yards in five of the 10 games played last season prior to going down. This is a perfect matchup for Burrow to record his first 300-yard game this year.

Why Jaguars can cover

The Jaguars have struggled to stop the pass, allowing 302.3 yards through the air. Joe Burrow and the Bengals' air attack will need to exploit the Jaguars' secondary, and wide receivers Ja'Marr Chase and Tyler Boyd will likely be the top two pass-catchers. Tee Higgins is dealing with a shoulder injury and his status for Thursday Night Football game is up in the air.

Chase leads the Bengals in receiving yards with 220 and a team-high four touchdowns. Boyd leads Cincinnati in catches with 14 for 141 yards and one touchdown. Boyd and Chase both have caught eight passes that have gone for first downs, helping keep the offense on the field. 

How to make Jaguars vs. Bengals picks 

SportsLine's model is leaning over on the total, projecting the teams to combine for 48 points. The model also says one side of the spread hits in well over 50 percent of simulations. You can only see which side to back at SportsLine. 

So who wins Jaguars vs. Bengals on Thursday Night Football? And which side of the spread cashes in well over 50 percent of the time? Visit SportsLine now to see which side of the Jaguars vs. Bengals spread to jump on, all from the advanced model that is up over $7,900 on its NFL picks, and find out.