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Two struggling teams just looking for the season to come to a close meet up in the desert in Week 16 when the Arizona Cardinals host the Atlanta Falcons. The Cardinals have been the odd man out in a loaded NFC West with a 3-11 record while losing six in a row. The Falcons are just 5-9 after entering the year with postseason aspirations after nearly stealing the NFC South late last season. Additionally, Atlanta won't reap the rewards of its disastrous year as the Los Angeles Rams own the Falcons' first-round pick this season.

Kickoff from the State Farm Stadium is set for 4:05 p.m. ET. The Falcons are 2.5-point road favorites per the latest Falcons vs. Cardinals odds from DraftKings while the over/under for total points scored is 47.5. Before making any Falcons vs. Cardinals picks of your own, make sure to look at the top NFL picks from the SportsLine Projection Model, which simulates every NFL game 10,000 times. 

Where to watch Falcons vs. Cardinals on Sunday

When: Sunday, Dec. 21
Time: 4:05 p.m. ET
TV: FOX
Stream: Fubo  
Follow along: CBS Sports App

Falcons vs. Cardinals betting preview

Odds: Falcons -2.5, over/under 47.5

The Cardinals are just 3-11 this year but they've been good when it comes to the Over, with that side of the total hitting in nine of their 15 games this year. They've also been better against the spread at 6-8. Atlanta is 7-7 to the Over this year and 6-7-1 ATS. 

Falcons vs. Cardinals SGP

Bet it at DraftKings:

Model's Falcons vs. Cardinals score prediction, picks

The model has the Falcons winning as road favorites 57% of the time, and it also likes Atlanta covering as that occurs in 53% of sims. The model also projects a higher-scoring affair between these struggling teams with the Over hitting in 58% of simulations. 

Falcons vs. Cardinals score prediction: Falcons 28, Cardinals 25

Want more Week 16 NFL picks?

You've seen the model's best bets for Atlanta Falcons vs. Arizona Cardinals. Now, get against the spread, total and money-line picks for every Week 16 NFL game here, all from the model that's simulated every game 10,000 times.