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Teams coming off big wins clash when the Columbia Lions battle the Cornell Big Red in a key Ivy League opener on Monday afternoon. Columbia is coming off a 106-51 win over Penn State-Abington on Wednesday, while Cornell rolled to a 133-65 victory over Alfred State on Friday. The Lions (11-3), who finished eighth in the league last year at 1-13, are 4-3 on the road this season. The Big Red (7-6), who finished second in the Ivy in 2024-25 at 9-5, are 4-0 on their home court this year.

Tipoff from Newman Arena in Ithaca, N.Y., is set for 5 p.m. ET. Cornell is a 2.5-point favorite in the latest Columbia vs. Cornell odds from SportsLine consensus, while the over/under for total points scored is 172.5. Before making any Cornell vs. Columbia picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 10 on a sizzling 9-1 run on its top-rated over/under college basketball picks dating back to last season. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns. 

Now, the model has simulated Columbia vs. Cornell 10,000 times and just revealed its coveted men's college basketball picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several men's college basketball odds and men's college basketball betting lines for Cornell vs. Columbia:

Columbia vs. Cornell spread:    

Cornell -2.5 at DraftKings Sportsbook

Columbia vs. Cornell over/under:    

172.5 points

Columbia vs. Cornell money line:    

Columbia +124, Cornell -149

Columbia vs. Cornell picks:    

See picks at SportsLine

Columbia vs. Cornell streaming:

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How to make Columbia vs. Cornell picks

SportsLine's model is going Over on the total (168.5 points). The Over has hit in each of the last six meetings between the teams. 

The model projects the Lions to have three players register 12.6 points or more, led by Kenny Noland's projected 19.2 points. The Big Red, meanwhile, are projected to have three players scoring 14.7 or more points, led by Cooper Noard, who is projected to score 22.3 points. The model projects a combined total of 171 points as the Over clears in 51% of simulations.

The model also says one side of the spread hits over 70% of the time. You can only see that pick at SportsLine.

So who wins Cornell vs. Columbia, and which side of the spread hits over 70% of the time? Visit SportsLine now to see which side of the Columbia vs. Cornell spread to back, all from the advanced model that has simulated this game 10,000 times, and find out.