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The Wichita State Shockers and the No. 12 Houston Cougars are set to square off in an American Athletic matchup at noon ET on Saturday at the Fertitta Center and the action will be broadcast live on CBS. The Cougars are 13-2 overall and 8-0 at home, while Wichita State is 9-4 overall and 3-0 on the road. Houston has won six of eight head-to-head matchups with Wichita State since 2018 but the programs have split those eight meetings against the spread.

In their most recent matches, the Shockers won 68-63 as 7.5-point underdogs to help them win the regular-season AAC crown. This time around, the Cougars are favored by 12.5 points in the latest Houston vs. Wichita State odds from Caesars Sportsbook and the over-under is set at 133.5. Before entering any Wichita State vs. Houston picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Houston vs. Wichita State. You can head to SportsLine to see its picks. Here are several college basketball odds for Wichita State vs. Houston:

  • Houston vs. Wichita State spread: Houston -12.5
  • Houston vs. Wichita State over-under: 133.5 points

What you need to know about Houston

Houston had enough points to win and then some against the South Florida Bulls on Wednesday, taking the game 83-66. Forward Josh Carlton was the offensive standout of the matchup for Houston, posting a double-double on 30 points and 11 rebounds.

Carlton is averaging 11.1 points and 5.3 rebounds per game this season, but he's had a couple of 20-point games in his last three contests. With Marcus Sasser out for the season because of a toe injury, players like Carlton, Kyler Edwards and Fabian White will all have to take on larger scoring loads.

What you need to know about Wichita State

Meanwhile, the contest between Wichita State and the Memphis Tigers on Saturday was not particularly close, with Wichita State falling 82-64. Guard Tyson Etienne (17 points) and guard Dexter Dennis (16 points) were the top scorers for the Shockers.

Wichita State shot just 29.5 percent from the floor and it was the second loss in three games where the Shockers shot under 37 percent from the floor. Isaac Brown's squad will need to identify ways to get to their spots and knock down shots quickly against a Houston squad that ranks 11th in the nation in field-goal percentage allowed (37.2).

How to make Houston vs. Wichita State picks

The model is leaning over on the total and it's also generated a point-spread pick that is hitting in 70 percent of simulations. You can only see the pick at SportsLine.

So who wins Wichita State vs. Houston? And which side of the spread hits 70 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.