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A Big Ten battle is on tap between the No. 4 Ohio State Buckeyes and the Penn State Nittany Lions at 8 p.m. ET Thursday at Bryce Jordan Center. Penn State is 7-10 overall and 6-3 at home, while the Buckeyes are 17-4 overall and 6-3 on the road. Ohio State won the last meeting between the teams on Jan. 27, 83-79. 

The Buckeyes are favored by five points in the latest Penn State vs. Ohio State odds from William Hill Sportsbook, and the over-under is set at 146. Before entering any Ohio State vs. Penn State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Penn State vs. Ohio State. You can head to SportsLine to see its picks. Here are several college basketball odds for Ohio State vs. Penn State:

  • Penn State vs. Ohio State spread: Penn State +5
  • Penn State vs. Ohio State over-under: 146 points

What you need to know about Penn State

Penn State lost 62-61 to the Nebraska Cornhuskers on Sunday. Nebraska scored on a decisive layup with 12 seconds remaining. The top scorer for Penn State was Myreon Jones (18 points). The Nittany Lions have lost three of their past four games. 

John Harrar had 11 rebounds vs. Nebraska. He has totaled 11-plus rebounds 10 times in his career. The Penn State bench totaled only 10 points in the loss on Sunday. 

What you need to know about Ohio State

OSU didn't have much trouble with the Indiana Hoosiers at home on Saturday in a 78-59 romp. Justice Sueing dropped a double-double on 16 points and 10 rebounds and E.J. Liddell had 19 points. The Buckeyes have won six consecutive games. OSU scored 21 points off 15 turnovers. 

Sueing has four double-doubles this season. Duane Washington Jr. leads returning Ohio State players vs. Penn State with 12.8 points per game in four career matchups. Ibrahima Diallo (knee) is questionable for Thursday's game.   

How to make Penn State vs. Ohio State picks

The model has simulated Penn State vs. Ohio State 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Ohio State vs. Penn State? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to see which side of the Ohio State vs. Penn State spread to jump on Thursday.