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Having been assigned to the Midwest Region as a No. 3 seed, the Wisconsin Badgers have the benefit of essentially playing home games the first two rounds of the 2022 NCAA Tournament in Milwaukee. Wisconsin needed that home-state advantage in a 67-60 win over Colgate and now it will be hoping for another raucous crowd as it takes on the Iowa State Cyclones for a chance to make its first Sweet 16 appearance since 2017. However, Iowa State is coming off a thrilling upset of LSU and is also looking to make its first Sweet 16 run since 2017.

Tip-off is scheduled for 6:10 p.m. ET at the Fiserv Forum. The Badgers are four-point favorites in the latest Wisconsin vs. Iowa State odds from Caesars Sportsbook, and the over-under for total points scored is set at 127. Before making any Iowa State vs. Wisconsin picks, be sure to check out the NCAA Tournament 2022 predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Wisconsin vs. Iowa State and revealed its coveted picks and predictions for the NCAA Tournament 2022. You can head to SportsLine to see all of the model's college basketball picks. Here are several college basketball odds and trends for Iowa State vs. Wisconsin:

  • Wisconsin vs. Iowa State spread: Wisconsin -4
  • Wisconsin vs. Iowa State over-under: 127 points
  • Wisconsin vs. Iowa State money line: Wisconsin -190, Iowa State +160
  • ISU: The Cyclones have covered in just one of their last six games against Big Ten opponents
  • WISC: The Badgers are 5-10 ATS in their last 15 games

Why Wisconsin can cover

After losing to Nebraska on the final day of the regular season to lose out on what would have been sole possession of first place in the Big Ten and then being ousted my Michigan State in the Big Ten tournament, the Badgers snuck by No. 14 seed Colgate 67-60 on Friday. Jonathan Davis, the Big Ten Player of the Year, had a massive night with 25 points and eight rebounds, while Tyler Wahl recorded 15 points, nine rebounds and four assists.

Wisconsin struggled to run Colgate off its spots, as the Raiders shot 10-for-22 from the 3-point line. However, the Badgers were able to make things difficult on Colgate inside the arc, where the Raiders shot just 34.3 percent. If Wisconsin can contain Tyrese Hunter from outside and get more from its own sharpshooter, Brad Davison (four points on 1-for-5 shooting against Colgate), it should be in a solid position on Sunday.

Why Iowa State can cover

Despite going 7-11 in Big 12 play, Iowa State earned an at-large bid to the 2022 NCAA Tournament and drew a solid first-round matchup against an LSU squad that just had to fire head coach Will Wade for major alleged recruiting violations. LSU ranked 186th in the nation in offensive rating (102.3), while Iowa State ranked 26th in defensive rating (92.8) and 10th in adjusted defensive efficiency (89.6).

Wisconsin can be similarly challenged on offense from time to time, ranking 125th in the nation in offensive rating (105.5). That should bode well for an Iowa State defense that has a lot of confidence after collecting 15 steals and forcing 19 turnovers against the Tigers. If Tyrese Hunter can stay hot (7-for-11 from the 3-point line in the first round), the Cyclones might have just enough to pull off another upset and slip into the Sweet 16.

How to make Iowa State vs. Wisconsin picks

SportsLine's model is leaning over on the point total, projecting the teams to combine for 135 points. The model also says one side of the spread hits over 50 percent of the time. You can only see the model's pick at SportsLine.

So who wins Wisconsin vs. Iowa State? And which side of the spread hits over 50 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.