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The No. 11 Indiana Hoosiers will try to win their first bowl game in almost 30 years when they square off against the Ole Miss Rebels on Saturday in the 2021 Outback Bowl at Raymond James Stadium in Tampa, Fla. The Hoosiers (6-1) have lost five straight bowl games. Their last bowl victory came on Dec. 30, 1991, when they shut out Baylor, 24-0, in the Copper Bowl. On Saturday they'll meet an Ole Miss program that is 11-2 in its last 13 bowl games and has won 63.9 percent of its bowls, which ranks second nationally among teams with at least 25 appearances. 

Kickoff is set for 12:30 p.m. ET. William Hill Sportsbook pegs the Hoosiers as 9.5-point favorites in the latest Indiana vs. Ole Miss odds, up two points from the opening line. While the over-under for total points scored is 67. Before making any Ole Miss vs. Indiana picks, check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It enters bowl season a sizzling 56-36 on all top-rated picks, returning over $400. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ole Miss vs. Indiana in the Outback Bowl 2021. You can visit SportsLine now to see the picks. Here are the college football odds and betting trends for Indiana vs. Ole Miss:

  • Indiana vs. Ole Miss spread: Hoosiers -9.5
  • Indiana vs. Ole Miss over-under: 67 points
  • Indiana vs. Ole Miss money line: Hoosiers -360, Rebels +285
  • IU: WR Ty Fryfogle leads the Big Ten in yards per reception (20.2)
  • MISS: Matt Corral leads the country in total offense (384.9 yards per game)

Why Indiana can cover

Fryfogle is having one of the best seasons by any receiver in the FBS. The senior receiver from Lucedale, Miss., leads the Big Ten and ranks 10th in the country in yards per reception (20.2). He also ranks third in the conference in receiving touchdowns (seven). For his efforts this season he was named a third team All-American by the Associated Press.

In addition, Indiana faces an Ole Miss team that will be without multiple playmakers on offense. Receiver Elijah Moore, a first team All-American who leads the nation in both receptions per game (10.8) and receiving yards per game (149.1), opted out of the season before the Rebels' last regular season game. So did tight end Kenny Yeboah, who ranks fifth among tight ends in receiving touchdowns (six) and eighth in receiving yards (524). Ole Miss also may be without running back Jerrion Ealy and receiver Braylon Sanders due to injury.

Why Ole Miss can cover

Even without those key pieces, Ole Miss has quarterback Matt Corral leading one of the most prolific offenses in the country. The Rebels average 562.4 yards per game, which leads the SEC and ranks third in the nation. A big part of that is their passing offense, which averages 344.8 yards a game, ranking sixth in the FBS.

In addition, receiver Dontario Drummond has emerged as a reliable pass-catching threat. The senior from Laurel, Miss., has caught a touchdown in four straight games. He also has 12 receptions for 195 yards in those four games. In 17 previous games for Ole Miss, he had just 20 catches for 300 yards and zero touchdowns.

How to make Indiana vs. Ole Miss picks

SportsLine's model is leaning under the total. In fact, it says both teams will combine for around 60 points. It also has generated an against-the-spread pick that cashes in almost 60 percent of simulations. You can only get the pick at SportsLine. 

So who wins Ole Miss vs. Indiana? And which side of the spread hits almost 60 percent of the time? Visit SportsLine right now to see which side of the Indiana vs. Ole Miss spread to back, all from the advanced model on a 56-36 run on its top-rated college football picks this season.