Florida vs. Vanderbilt odds, line: 2021 college football picks, Week 6 predictions from proven model

SportsLine's model just revealed its college football picks for Vanderbilt vs. Florida

By Scout Staff

Oct 9, 2021 at 8:16 am ET • 2 min read

Florida cannot afford another slip-up after losing to Kentucky last week. The Gators are now two games behind Georgia and Kentucky in the SEC East. They have won their last seven games against Vanderbilt and have come away victorious in 29 of the last 30 meetings. The Commodores were shut out in a 56-0 final last time these teams met at Ben Hill Griffin Stadium.

Kickoff is set for noon ET. The Gators are 39-point favorites in the latest Florida vs. Vanderbilt odds at Caesars Sportsbook, while the over-under for points scored is 59.5. Before entering any Vanderbilt vs. Florida picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Florida vs. Vanderbilt. You can head to SportsLine to see its picks. Here are several college football odds for Vanderbilt vs. Florida:

Florida vs. Vanderbilt spread: Florida -39
Florida vs. Vanderbilt over-under: 59.5 points

What you need to know about Florida

Vanderbilt has only played one conference game so far this season. The Commodores were blown out in a 62-0 final at home against Georgia, despite Bulldogs starting quarterback JT Daniels only playing one quarter. They are now tasked with slowing down an angry Florida team on Saturday afternoon, as the Gators are coming off a disappointing loss at Kentucky.

Florida enters this game with the nation's third-best rushing attack, averaging 292.2 rushing yards per game. Quarterback Emory Jones ranks fifth in the SEC with 438 rushing yards and he should have a field day against a Vanderbilt run defense that is No. 112 nationally. The motivated Gators have too much talent for the Commodores to deal with at The Swamp.

What you need to know about Vanderbilt

Meanwhile, Vanderbilt squeaked by the Connecticut Huskies by less than a field goal, winning 30-28 last week. Wide receiver Will Sheppard was the offensive standout of the game for the Commodores, catching eight passes for two TDs and 119 yards. That receiving effort made it the first game that Sheppard has posted more than 100 yards receiving.

The Commodores are averaging just 16.0 points per game this season, which ranks 126th in the nation. Vanderbilt's defense is giving up 35.0 points per game on average. The Commodores have lost seven straight against Florida, but they covered as 31.5 point underdogs against the Gators last year.

How to make Florida vs. Vanderbilt picks

The model has simulated Florida vs. Vanderbilt 10,000 times and the results are in. The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Vanderbilt vs. Florida? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.