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The Louisville Cardinals will try to remain unbeaten when they face the Indiana Hoosiers in Indianapolis on Saturday afternoon. Louisville opened the season with a 39-34 win against Georgia Tech in Atlanta before cruising to a 56-0 win against Murray State. Indiana suffered a 23-3 loss to No. 3 Ohio State in Week 1, but it bounced back with a 41-7 win over Indiana State. This is the first meeting between these teams since 1986, when Indiana beat Louisville in a 21-0 final. 

Kickoff is set for noon ET on Saturday at Lucas Oil Stadium. Louisville is favored by 10 points in the latest Indiana vs. Louisville odds, while the over/under is set at 50.5 points, per SportsLine consensus. Before entering any Louisville vs. Indiana picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model has set its sights on Louisville-Indiana. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

  • Indiana vs. Louisville spread: Louisville -10
  • Indiana vs. Louisville over/under: 50.5 points
  • Indiana vs. Louisville money line: Indiana: +288, Louisville: -373
  • Indiana vs. Louisville picks: See picks here

Why Indiana can cover

Indiana opened the season with a brutal matchup against No. 3 Ohio State, but the Hoosiers were able to cover the 30-point spread in that 23-3 final. Their defense stepped up again last week, holding Indiana State to just one touchdown in a 41-7 blowout. Quarterback Tayven Jackson completed 18 of 21 passes for 236 yards in his first career start, earning the start with veteran Dexter Williams sidelined by a torn knee ligament. 

The Hoosiers racked up 558 total yards of offense while holding Indiana State to just 93 total yards. Sophomore running back Jaylin Lucas leads Indiana's rushing attack with 21 carries for 112 yards and two touchdowns, averaging 5.3 yards per attempt. Louisville has only covered the spread once in its last five games against Big Ten opponents. 

Why Louisville can cover 

While Indiana is still trying to nail down its starting quarterback, Louisville's offense is rolling early in the season. The Cardinals scored 39 points in a win over Georgia Tech before putting up 56 points in a shutout win over Murray State. Senior quarterback Jack Plummer has completed 34 of 53 passes for 494 yards and four touchdowns. 

His top target is junior wide receiver Jamari Thrash, who has 10 receptions for 170 yards and three scores. Junior running back Jawhar Jordan has been a key part of the offense as well, rushing for 231 yards and two touchdowns on 14 carries. Louisville has won eight of its last 10 games, covering the spread seven times during that stretch. See which team to pick here.

How to make Indiana vs. Louisville picks

The model has simulated Louisville vs. Indiana 10,000 times and the results are in. The model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Indiana vs. Louisville, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Louisville vs. Indiana spread to jump on, all from the advanced computer model that's up nearly $2,500 on its top-rated college football spread picks since its inception, and find out.