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The No. 18 Oklahoma Sooners will be looking to bounce back from their first loss of the season when they face the TCU Horned Frogs on Saturday afternoon. Oklahoma won three consecutive games before losing to Kansas State as a heavy favorite last week. TCU is trying to remain unbeaten following its 42-34 win at SMU last Saturday. 

Kickoff is set for noon ET. The Sooners are 6-point favorites in the latest TCU vs. Oklahoma odds from Caesars Sportsbook, while the over/under is set at 69. Before entering any Oklahoma vs. TCU picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on TCU vs. Oklahoma. You can head to SportsLine to see its picks. Here are several college football odds for TCU vs. Oklahoma:

  • TCU vs. Oklahoma spread: Oklahoma -6
  • TCU vs. Oklahoma over/under: 69 points
  • TCU vs. Oklahoma picks: See picks here

Why TCU can cover

TCU is off to an excellent start to its 2022 campaign, taking down Colorado, Tarleton State and SMU in its first three games. The Horned Frogs were 2.5-point favorites in their 42-34 win at SMU last week, as they raced out to a 28-7 lead before hanging on down the stretch. Quarterback Max Duggan completed 22 of 29 passes for 278 yards and three touchdowns in the win. 

Junior running back Kendre Miller was outstanding as well, rushing 17 times for 142 yards and a touchdown. TCU has been tough to beat at home, going 8-3 in its last 11 games at Amon G. Carter Stadium. Oklahoma is coming off a rough performance at home and now has to go on the road to face an inspired team, making this a bad scheduling spot for the Sooners. 

Why Oklahoma can cover

Oklahoma is coming off its first loss of the season, but the Sooners are now available at a discounted price in this game. Their offense has scored at least 33 points in all four of their games this season, so it will be difficult for TCU's offense to keep pace. Junior quarterback Dillon Gabriel has thrown for more than 1,000 yards and 11 touchdowns, and he has still not thrown an interception this year. 

Senior running back Eric Gray is one of the top running backs in the country, averaging 7.5 yards per carry on 53 attempts. Junior wide receiver Marvin Mims, who has 18 receptions for 397 yards and three touchdowns, will be the best wideout that TCU has seen this year. Oklahoma is on an eight-game winning streak against TCU and has covered the spread in six of the last seven meetings. 

How to make TCU vs. Oklahoma picks

The model has simulated Oklahoma vs. TCU 10,000 times and the results are in. The model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the pick at SportsLine.

So who wins TCU vs. Oklahoma? And which side of the spread hits in well over 60% of simulations? Visit SportsLine now to find out which side of the Oklahoma vs. TCU spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.