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Legendary head coach Johnny Majors will be honored in Knoxville on Saturday when Tennessee hosts Pittsburgh. Majors had a pair of stints as Pitt's head coach, taking the team to the 1976 national championship. He was also an All-American running back with the Vols and later coached them for 16 seasons. This game, dubbed the Johnny Majors Classic, will be the first meeting between the schools since 1983. The Panthers are coming off a 51-7 win over UMass, while Tennessee notched a 38-6 victory over Bowling Green.

Kickoff is set for noon ET. The Panthers are four-point favorites in the latest Tennessee vs. Pittsburgh odds from Caesars Sportsbook, while the total is 56. Before finalizing any Pittsburgh vs. Tennessee picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Tennessee vs. Pitt. You can head to SportsLine to see its picks. Here are several college football odds for Pitt vs. Tennessee:

  • Tennessee vs. Pittsburgh spread: Pittsburgh -4
  • Tennessee vs. Pittsburgh over-under: 56 points

What you need to know about Tennessee

The Volunteers got past the Bowling Green Falcons last Thursday, and the extra yardage (476 yards vs. 218 yards) paid off in the 38-6 win. The Vols jumped to an early 14-0 lead, but then allowed the Falcons to scrap their way back into the game by halftime. But a strong third quarter helped Tennessee pull away against the MAC squad. 

The game was all but wrapped up at the end of the third, by which point Tennessee had established a 28-6 advantage. The Vols can attribute much of their success to running back Jabari Small, who rushed for two TDs and 124 yards on 23 carries. Tiyon Evans, who is questionable for this matchup (undisclosed), added 116 yards and a score on 16 carries. Quarterback Joe Milton III struggled with accuracy in his Tennessee debut, completing just 11-of-13 passes. He did, however, score two rushing touchdowns. 

What you need to know about Pittsburgh

Pitt is led by veteran quarterback Kenny Pickett, who is a four-year starter. He is coming off a season in which he completed 61.1 percent of his passes for 2,408 yards and 13 touchdowns. Pickett got off to a strong start last week, completing 27 of 37 pass attempts for 272 yards and two scores. He sat out the fourth quarter of the blowout.

Nine different players attempted a run for Pitt last week, totaling 223 yards and five touchdowns on the ground. The Panthers' defense is headlined by linebacker John Petrishen, who had two sacks against the Minutemen. Tennessee allowed three sacks in its win over Bowling Green. The Vols are still getting used to their new schemes, which is why the betting line has swung towards Pitt. 

How to make Pitt vs. Tennessee picks

The model has simulated Tennessee vs. Pittsburgh 10,000 times and the results are in. The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Tennessee vs. Pittsburgh? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.