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The No. 19 Utah Utes (8-3) host the Colorado Buffaloes (4-7) in a Pac-12 South clash on Friday at Rice-Eccles Stadium in Salt Lake City, Utah. Utah has already clinched a spot in the Pac-12 Championship Game, while Colorado will fail to qualify for the postseason for the 13th time since the 2006 season. The Utes are coming off a huge 38-7 win over the then-No. 3 Oregon Ducks. The Buffaloes won their home finale over Washington 20-17 last weekend. Both teams are 5-6 against the spread in 2021.

Kickoff is at 4 p.m. ET. The Utes are favored by 24 points in the latest Utah vs. Colorado odds from Caesars Sportsbook, and the over-under is set at 52. Before making any Colorado vs. Utah picks, you need to check out the college football predictions and betting advice from the red-hot computer simulation model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Utah vs. Colorado and just locked in its CFB picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for Colorado vs. Utah:

  • Utah vs. Colorado spread: Utah -24
  • Utah vs. Colorado over-under: 52 points
  • Utah vs. Colorado moneyline: Utah -2400, Colorado +1100

What you need to know about Utah

Utah made easy work of the Oregon Ducks last Saturday and notched a decisive 38-7 victory. The contest was pretty much decided by the half, when the score had already reached 28-0. Utah running back Tavion Thomas had a big day, racking up three rushing touchdowns.

With the College Football Playoff out of reach, and a spot already locked up in the Pac-12 title game, Utah doesn't have a ton to play for this week against Colorado. However, Utah has excelled defensively all season, which could bode well for their chances at covering the spread against a Colorado team that has been among the worst offensive teams in the nation in 2021. 

What you need to know about Colorado

Meanwhile, it was all tied up 10-10 at the half for the Buffaloes and the Washington Huskies on Saturday, but Colorado stepped up in the second half for a 20-17 win. Colorado's only offensive touchdown came on a rush from quarterback Brendon Lewis.

The main reason for the Buffaloes disappointing record in 2021 has been their offensive struggles. Through 11 games, Colorado is averaging 19.3 points and only 267.5 total yards per game. Lewis has shown signs of improvement, but he still has a long way to go before he can be considered a top tier Pac-12 quarterback. Regardless of the outcome, this will be Colorado's last game of the season, so there will naturally be some added motivation to send the Buffs' senior class out on a high note.

How to make Utah vs. Colorado picks

The model is leaning under on the point total, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the model's Colorado vs. Utah pick at SportsLine.

So who wins Friday's Colorado vs. Utah matchup? And which side of the spread is hitting more than 60 percent of the time? Visit SportsLine right now to see which side of the Utah vs. Colorado spread to back on Friday, all from the advanced model on a 39-25 run on its top-rated college football picks, and find out.