Finalizing your NFL Playoff Challenge lineups means choosing between stars like Derrick Henry who will play on Wild Card Weekend, and stars who earned a bye like Patrick Mahomes. The longer a player remains in your NFL Playoff Challenge lineups, the more points they'll score, so it could pay to roster Aaron Rodgers, Davante Adams, or Tyreek Hill on Wild Card Weekend even though they won't generate any points.

Which players should be part of your NFL Playoff Challenge strategy this week? And which stars will crush your NFL Playoff Challenge picks? Before setting any 2021 NFL Playoff Challenge lineups, be sure to see the picks and advice from SportsLine's Mike McClure, a DFS pro who has won almost $2 million. 

McClure uses a powerful prediction model that simulates every snap of NFL action in every game 10,000 times, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best values that he shares only with members at SportsLine.

He absolutely crushed his DFS picks during the the 2019 NFL regular season, finishing as high as the top 1 percent of tournaments on DraftKings and returning as much as 40x return in some higher-stakes tournaments. He then continued his roll in the postseason, cashing on every single lineup he posted for the divisional round. Anyone who has been following him has seen some huge returns. 

Now he's turned his attention to the 2021 NFL Playoff Challenge. Go here to see his full Wild Card Round lineups. 

Top NFL Playoff Challenge picks for the 2021 Wild Card Round

One of McClure's top NFL Playoff Challenge picks for the 2021 Wild Card Round: Saints running back Alvin Kamara. Along with teammate Taysom Hill, Kamara is a multi-threat player who can score any time he touches the ball. Despite missing Week 17 due to COVID-19, Kamara finished with 932 yards and 16 touchdowns, both career-highs, and caught 83 passes for 756 yards and five more scores.

Not only is Kamara a valuable asset during Wild Card Weekend against the Bears, but he would receive a 2x multiplier next week if he remains in your NFL Playoff Challenge lineup. Kamara is expected to return to the lineup on Sunday, his first available day back from the reserve/COVID-19 list. Lock him into your NFL Playoff Challenge lineups this week and reap the benefits until the Saints are knocked out.

How to build 2021 NFL Playoff Challenge lineups 

McClure is also targeting a pick that could go off for big numbers Wild Card Weekend because of a dream matchup. This pick could be the difference between winning your NFL Playoff Challenge or going home with nothing. You can see who it is over at SportsLine.

So what is the optimal 2021 NFL Playoff Challenge lineups for Wild Card Weekend? Visit SportsLine now to see the full optimal tournament lineups for the NFL Playoff Challenge this weekend from a professional DFS player who has almost $2 million in career winnings, and find out.