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Future Hall of Famer Albert Pujols resumes his quest for career home run No. 700 when he and the St. Louis Cardinals (87-62) face the San Diego Padres (82-66) on Wednesday at Petco Park. The 42-year-old Pujols, who plans to retire after this season, has 698 career home runs, which ranks fourth all-time. Only Barry Bonds (762), Hank Aaron (755) and Babe Ruth (714) have more. San Diego is a -135 favorite in the latest Padres vs. Cardinals odds from Caesars Sportsbook, while St. Louis is a +115 underdog. The over/under for runs scored is 7.5.

First pitch is set for 9:40 p.m. ET from San Diego. The game is one of 15 on the MLB schedule for Wednesday. Elsewhere in the majors, the Yankees slugger Aaron Judge can tie Roger Maris' storied American League record for most home runs in a season, against the Pirates, and the Guardians and White Sox square off in Chicago. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 321-272 on top-rated MLB money-line picks since the start of the 2021 season, returning more than $600 for $100 bettors during that span. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Wednesday. They all involve games at 6:40 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 18-1. You can only see the model's MLB picks at SportsLine. 

Top MLB picks today

The model, which ran 10,000 simulations on each of Wednesday's games, likes Kansas City (+110) to knock off Minnesota. Once the leaders in the AL Central, the Twins (73-75) have struggled on the road in the second half of the season, going 5-21 in their last 26 games away from Target Field. Meanwhile, the Royals (59-89) have been much better at home (35-41) than on the road (24-48) this season.

Kansas City faces a Minnesota team that has struggled in September, going 6-14 in its last 20 games. In September, the Twins have scored just 64 runs and have an OPS of .663. Just four teams have been worse in both offensive categories. See who else to back right here.

How to make MLB picks and parlays for Wednesday

The model also locked in three other best bets for Wednesday, including a play on an even bigger underdog. You can see the model's MLB Wednesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of almost 18-1? And what underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 321-272 run on top-rated MLB money-line picks since the start of 2021.