2022 MLB playoffs: Dodgers vs. Padres odds, line, NLDS Game 1 picks, predictions from proven model
SportsLine's model simulated the Division Series opener between the San Diego Padres and Los Angeles Dodgers 10,000 times

The 2022 MLB playoffs roll on and Game 1 of the NLDS has the San Diego Padres and Los Angeles Dodgers battling it out on Tuesday night. The Dodgers owned the best record in the majors (111-51), securing the top seed in the National League. Meanwhile, San Diego (89-73) defeated the New York Mets 2-1 in the Wild Card round to advance to the NLDS. Mike Clevinger (7-7, 4.33 ERA) will start for the Padres, with the Dodgers countering with Julio Urias (17-7, 2.16 ERA).
The first pitch is set for 9:37 p.m. ET from Dodger Stadium. Los Angeles is listed at -250 on the money line (risk $250 to win $100) in the latest Dodgers vs. Padres odds from Caesars Sportsbook. The over-under for total runs scored is 7.5. Before making any Padres vs. Dodgers picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.
The SportsLine Projection Model simulates every MLB game 10,000 times, and it enters the divisional round on a 20-11 roll on top-rated MLB money-line picks, returning more than $600. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.
Now, the model has set its sights on Dodgers vs. Padres, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Dodgers vs. Padres:
- Padres vs. Dodgers money line: Dodgers -250, Padres +205
- Padres vs. Dodgers run-line: San Diego +1.5 (-105)
- Padres vs. Dodgers over-under: 7.5 runs
- SD: Padres are 6-0 in their last six Tuesday games
- LAD: Under is 4-0 in the Dodgers' last four overall
- Padres vs. Dodgers picks: See picks here
Why you should back the Dodgers
Catcher Will Smith is a phenomenal athlete behind the plate with incredible defensive instincts. Smith has a terrific throwing arm while framing pitches at a high rate. The 27-year-old can hit for power and consistently get on base as he finished the regular season with an average of .260 along with 24 home runs and 87 RBI.
Third baseman Justin Turner is another reliable outlet for this team. The veteran displays a solid glove and is a proven performer in October as he sports a career .846 postseason OPS. This season, he belted 13 home runs with 81 RBI and 36 doubles. He also finished the season strongly with a .322 batting average over his last 24 games.
Why you should back the Padres
Right fielder Juan Soto has been a smooth addition to this ball club as he can hit for average with superb home-run power. The two-time All-Star has electric hands, quickly turning on a pitch he likes, while also drawing a fair share of walks. In the Wild Card round, Soto had a batting average of .333 with two runs driven in. In his last outing, he went 2-for-4 with two base hits.
Third baseman Manny Machado is an all-around weapon for San Diego. A two-time Gold Glove winner, Machado plays stellar defense at the corner with good instincts and a cannon of an arm. The six-time All-Star has displayed good power to all fields with outstanding bat control. During the regular reason, Machado led the team in batting average (.298), home runs (32) and RBI (102).
How to make Dodgers vs. Padres picks
SportsLine's model is leaning Over on the total, projecting 7.9 combined runs. It also says one side of the money line has all of the value. You can only get the model's MLB picks at SportsLine.
So who wins Padres vs. Dodgers? And which side of the money line has all of the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.















