The latest on the hot-button topics from the desk of commissioner Bud Selig, button-by-button:

On Biogenesis: "Comprehensive review. Sen. [George] Mitchell, who not only is my friend but has done great work for us, we're very proud of where we are, almost everything that he recommended is in place now. We have the toughest drug testing program in America and it's going to be enforced in the toughest way. That's all I can say. ... Anybody can read into that what they want. I'm just saying we need to protect our drug program and we will do that."

On expanded instant replay: "John Schuerholz, Joe Torre, Tony La Russa , they've been very thoughtful. My only point on instant replay is that we're willing to consider everything, but we have to be careful that we are consistent with what's in the best interest of game. And they've been very cautious. They're going to make recommendations to me, and so far they haven't. Sometime this year."

On Pete Rose's lifetime suspension: "Nothing's changed. Matter under review. And I'm the judge, and so I have to be very careful. But again, of course, Bart Giamatti and I happened to be very, very close friends. Bart did what he thought was right and I don't have anything else to say." Selig as of now is set to retire at the end of 2014. The matter has been "under review" for years. Will that review extend beyond Selig's tenure? "That’ll be up to whomever [follows Selig]."

On Jeffrey Loria and the Marlins: "GMs that I like, without naming them, all tell me they made a good deal with Toronto. Time will tell. Mr. Rickey used to say it was three-to-five years. People say they made a very good deal and that their farm system is productive. While it is easy to be critical, and it's been a tough situation down there -- nobody understands that better than I do -- I think we ought to wait a little bit and see how that all shakes out."

On the Oakland stadium situation: "Now we're in litigation. That's a very complex situation. I think the committee has done a remarkable job. Now we have litigation, so it's unfortunate. My job is to solve these problems in the best interest of the game. And we'll continue to try to do that. You have two teams with two entirely different views on the situation. That's why you have a commissioner."

On Tampa Bay's woeful attendance (from Tuesday's meeting with the Baseball Writers Association of America in New York): "Very disappointing and very worrisome. The Tampa Bay club ... is 2½ games out [of first place in the AL East] at the All-Star break. The first thing I do every morning is look at attendance at every game. It's beyond disappointing. [The Rays] have been so competitive and have really done a marvelous job in a situation that is economically not tolerable. ... Stu [Sternberg, Rays' owner] and I have had a lot of conversations and I think my patience is running as low as his, if not moreso."