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The Minnesota Twins and Boston Red Sox wrap up a four-game series on Monday at Fenway Park. The matchup will take place in a late-morning time slot as part of the 2022 Patriots' Day celebrations in Boston. Minnesota is 3-6 overall and 1-2 on the road this season. Boston is 5-4 overall and 2-1 at home in 2022.

First pitch is at 11:10 a.m. ET in Boston. Caesars Sportsbook lists Boston as the -140 favorite (risk $140 to win $100) on the money line, while the over-under, or total number of runs Vegas thinks will be scored, is nine in the latest Red Sox vs. Twins odds. Before making any Twins vs. Red Sox picks, you need to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters Week 2 of the 2022 season on a 216-181 roll on top-rated MLB money-line picks that dates back to last season, returning over $900 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in on Red Sox vs. Twins, and just locked in its picks and MLB predictions. You can visit SportsLine now to see the model's picks. Here are the MLB odds and trends for Twins vs. Red Sox:

  • Red Sox vs. Twins money line: Red Sox -140, Twins +120
  • Red Sox vs. Twins over-under: 9 runs
  • Red Sox vs. Twins run line: Red Sox -1.5 (+140)
  • MINN: The Twins are 36-48 in the last 84 road games
  • BOS: The Red Sox are 55-35 in the last 90 home games

Why you should back the Twins

The Twins will send Dylan Bundy to the mound, and the former top-five draft pick navigated five innings with only one hit and no runs in his first 2022 start. From there, Minnesota has offensive strengths, and Boston has some potential shortcomings. The Twins have 10 home runs in nine games, ranking in the top five of the American League, and Minnesota was No. 2 in the AL with 228 home runs in 2021. 

Minnesota also landed in the top five in slugging percentage (.423) a season ago, and the Twins have a 9.7 percent walk rate to begin the 2022 campaign. Boston left-hander Rich Hill gave up three earned runs in 4.1 innings in his first start, and the Red Sox have been below-average at the plate this season. Boston has a .286 on-base percentage, ranking in the bottom five of the AL and the Red Sox are the only team in the AL without a stolen base.

Why you should back the Red Sox 

Boston ranks above the AL average with 42 runs scored, and the Red Sox are striking out in only 21.6 percent of plate appearances. The Red Sox are in the top five of the AL in slugging percentage after ranking No. 2 last season, and Boston has the most doubles (20) in the American League. Bundy struggled to a 6.06 ERA in 2021, and right-handers posted a .527 slugging percentage against him last season. 

Minnesota's bullpen has an ugly 5.35 ERA in 2022, with 5.59 walks per nine innings. In terms of run prevention, Hill was excellent last season, and he owns a 3.17 ERA since the start of the 2015 campaign. Left-handers have a .328 slugging percentage against Hill in his career, including a paltry .266 mark a year ago. Minnesota has the worst batting average (.182) in the AL in 2022, with below-average marks in on-base percentage, slugging percentage and strikeout rate.

How to make Twins vs. Red Sox picks

SportsLine's model is leaning over on the total, as the simulation suggests the teams will combine for 9.8 runs. It also says one side of the money line has all the value. You can only get the model's pick at SportsLine. 

So who wins Red Sox vs. Twins? And which side of the money line has all the value? Visit SportsLine now to see which side to jump on, all from the advanced model that has crushed its top-rated MLB picks, and find out.