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Friday's 2025-26 NBA schedule will consist of five games. Among the notable NBA odds include Heat vs. Celtics (-6.5), 76ers vs. Knicks (-5), Spurs (-2.5) vs. Hawks, Bulls vs. Cavaliers (-7.5) and Thunder (-8) vs. Timberwolves. New York looks to extend its winning streak to seven in a row, while Boston is out to snap a two-game losing streak.  

What are the NBA best bets for Friday, and which combination of picks should you target in a Friday NBA parlay? Before locking in any NBA picks, you'll want to see the NBA predictions and betting advice from SportsLine's proven computer model.

New users can target the DraftKings promo code, which offers $200 in bonus bets if your bet wins:

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 9 of the 2025-26 NBA season on a sizzling 29-14 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has scoured the latest NBA odds and locked in three confident NBA best bets. If you successfully parlay its picks, you'd be looking at a payout of over +450. You can only see the model's NBA picks at SportsLine.

New users can also check out the latest FanDuel promo code and get $250 in bonus bets instantly at FanDuel if your $5 bet wins:

Top NBA picks for Friday, December 19

After simulating every game 10,000 times, the model is backing the Knicks (-198) to win over the 76ers in New York at 7 p.m. ET. New York has won the past five meetings with Philadelphia, including all four last season. The Knicks are 8-2 against the spread in their last 10 games, while the 76ers are 5-5 ATS in their last 10. The Knicks lead the Atlantic Division at 19-7, while Philadelphia is fourth in the division at 14-11.

Philadelphia will be without Kelly Oubre (knee). New York has been dominant on its home floor, going 13-1 at Madison Square Garden. The Knicks are also 5-1 within the division and 15-7 within the Eastern Conference. The 76ers, meanwhile, are 5-2 within the division and 12-10 against conference foes. They are 6-4 on the road.

The model is projecting five 76ers players to score 13.3 or more points, led by Tyrese Maxey, who is projected to score 25.6 points. The model also says six Knicks players will score 10.3 points or more, led by Jalen Brunson's 27.1 points. The model is also projecting that this game will be decided by a double-digit margin as New York covers in well over 60% of simulations. See which other NBA parlay picks to make here.

How to make NBA predictions for Friday, Dec. 19

The model also has locked in two more picks, including another bet that hits 60% of the time. You can only see the model's NBA parlay at SportsLine.

What are the model's top NBA parlay picks for Friday, and which best bets should you target for a chance at a payout of over +450? Visit SportsLine now to see NBA best bets from a model that's returned more than $10,000 on top-rated picks, and find out.