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The Arizona Cardinals and Los Angeles Rams are the frontrunners to claim the NFC West title, and the two teams will face off in Week 14. The Rams will travel to State Farm Stadium on Monday Night Football to face their divisional rivals for the second time this year. The Cardinals have won their last two games by double-digits and crushed Los Angeles by 17 at SoFi Stadium earlier this year. Rams tight end Tyler Higbee and star cornerback Jalen Ramsey are out due to COVID-19.

Kickoff is slated for 8:15 p.m. ET. Arizona is favored by three points in the latest Cardinals vs. Rams odds from Caesars Sportsbook, while the Over-Under is 51. Before locking in your Rams vs. Cardinals picks, make sure to check out the NFL predictions and betting advice from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,200 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 14 of the 2021 season on an incredible 132-94 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Rams vs. Cardinals 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model's picks. Now, here are several NFL odds and betting lines for Rams vs. Cardinals:

  • Cardinals vs. Rams spread: Cardinals -3
  • Cardinals vs. Rams over-under: 51
  • Cardinals vs. Rams money line: Cardinals -160, Rams +140 
  • LAR: Rams are 5-0 against the spread in their last five road games against the Cardinals 
  • ARI: Cardinals are 8-2 ATS in their last 10 games

Why the Rams can cover

While the Rams are 2-4 against the spread on the road, they're 4-2 straight-up and have found success in Arizona in recent years. Los Angeles has won five straight road contests against the Cardinals, who have suffered both of their losses this year at State Farm Field. The visitors have the offensive potential to keep pace with the favorites.

Scoring hasn't been a problem for Los Angeles over the last two weeks. While the Rams scored just 10 points in their first matchup following Robert Woods' season-ending knee injury, they've averaged 32.5 points per game since. Their top-five scoring offense has totaled 28 points per contest in 2021, and its third-ranked passing attack had plenty to do with that. Only the Tampa Bay Buccaneers have thrown more touchdown passes. Even the Cardinals' well-rounded defense could have a tough time slowing the Rams down when they get rolling.

Why Cardinals can cover

Arizona has been one of this year's most consistent teams against the spread. The Cardinals have covered nine times in 12 games, and only the Green Bay Packers have been more reliable. Their opponents haven't thrived on the road this year and are just 2-4 against the spread away from home.

Arizona boasts the NFL's third-ranked scoring offense despite not fielding a top-10 passing or rushing attack. The Cardinals average 28.6 points per game and excel at finishing drives on the ground. Only the Indianapolis Colts can top the Cardinals'' total of 19 rushing touchdowns. James Conner has proved to be an effective goal-line back with 12 rushing scores, and Kyler Murray has used his speed to tally five rushing scores of his own.

How to make Rams vs. Cardinals picks 

SportsLine's model is leaning under the point total, projecting the teams to combine for 49 points. The model also says one side of the spread cashes in well over 50 percent of simulations. You can only see the model's Rams vs. Cardinals picks at SportsLine. 

So who wins Rams vs. Cardinals on Monday Night Football? And which side of the spread cashes well over 50 percent of the time? Visit SportsLine now to see which side of the Rams vs. Cardinals spread to jump on, all from the advanced model that is up almost $7,200 on NFL picks, and find out.