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Patrick Mahomes taking on the Tennessee Titans and their decimated secondary could have been one of the top matchups of the year for NFL DFS players to target. Instead, Mahomes went down with a torn ACL last week as the Chiefs also saw their playoff hopes end. What level of trust can you put in his backup, Gardner Minshew, as he fills in against the Titans on Sunday afternoon? Minshew is $4,500 on FanDuel and $6,500 on DraftKings, making him a much cheaper option than other quarterbacks in the NFL DFS player pool such as Josh Allen, Dak Prescott and Joe Burrow, but not as cheap as Quinn Ewers, who will start in place of Tua Tagovailoa.

Who should you target at QB, and who are the sleepers in the NFL DFS player pool that can help differentiate your lineups? Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine's advanced NFL DFS lineup optimizer.

The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool.

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 15 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

Top NFL Week 16 DFS picks for Sunday

One of the optimizer's top DFS value picks for Sunday is Texans quarterback C.J. Stroud at $5,500 on DraftKings and $7,200 on FanDuel. He faces the Raiders, who have allowed opposing quarterbacks to have the eighth-highest rating this season. Stroud is also coming off one of his most complete performances of the season, throwing for 260 yards and three touchdowns with no interceptions and taking just one sack. See who else to pick here.

You can also bet Stroud to go Over 227.5 total passing yards at DraftKings:

The optimizer's NFL DFS strategy also includes building around Lions receiver Jameson Williams at $6,400 on DraftKings and $6,700 on FanDuel. Williams has a tremendous matchup against a Pittsburgh secondary that has given up the seventh-most yards to opposing receivers this season. Pittsburgh's defense won't have starting cornerback James Pierre (calf) and starting edge rusher T.J. Watt (lung) again this week. That should make life even easier on Detroit's passing game, and Williams is the value play from the unit as he comes in approximately $2,000 cheaper than Amon-Ra St. Brown on both sites. You can see the rest of the optimizer's NFL DFS picks here.

Bet Williams to go Over 69.5 receiving yards at DraftKings:

How to build Sunday Week 16 NFL DFS lineups

The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the optimizer's NFL DFS picks, at SportsLine. 

So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS optimizer that simulates every game 10,000 times, and find out.