Pete Prisco's NFL Week 12 Picks: Saints, Brees will outlast Rams

The Thanksgiving Day fare went just about as predicted, and now we can focus on some good games Sunday, led by the Saints-Rams in Los Angeles. 

Of course, I am not including the Battle of Ohio in those with intrigue, other than checking in to see if Cleveland has a chance to win a game -- which won't happen this week.

Tampa Bay at Atlanta

1 p.m. ET (Fox)

The Falcons impressed in winning at Seattle and now have three straight at home, starting with the Bucs. The Falcons lost to the Bucs at home last year, but this is a different Tampa Bay team, even after winning two straight. Atlanta wins their third straight here.

Pick: Falcons 27, Bucs 13


Cleveland at Cincinnati 

1 p.m. ET (CBS)

This battle of Ohio isn't a pretty one. The Bengals still have small playoff hopes, but the Browns are trying to play to keep from going winless. The Bengals defense has been solid all year, and will be so here to keep them in the race. Bengals take it.

Pick: Bengals 21, Browns 10


Tennessee at Indianapolis

1 p.m. ET (Fox)

It looks like Colts quarterback Jacoby Brissett will play here despite being in the concussion protocol. He's played well and almost beat the Titans earlier this season on the road. Tennessee is playing consecutive road games and hasn't played well lately. I think this is an upset. 

Pick: Colts 27, Titans 24


Buffalo at Kansas City

1 p.m. ET (CBS)

The Bills might be going back to Tyrod Taylor at quarterback here, which they should do. But does it matter? They are playing consecutive road games against a team that suffered an upset loss on the road last week. The Chiefs will get the offense going in this one. Look for a big game from Kareem Hunt

Pick: Chiefs 30, Bills 16


Miami at New England 

1 p.m. ET (CBS)

The Patriots have pretty much locked up the division, and now are playing for a top seed. The Dolphins are in a tailspin and might have to start Matt Moore at quarterback here. The Patriots continue to roll behind Tom Brady. Blowout. 

Pick: Patriots 33, Dolphins 13


Carolina at New York Jets

1 p.m. ET (Fox)

The Panthers come off their bye with a road game against the Jets, who are still alive in the playoff race. The Panthers are getting healthy and they seemed to find their offense before the bye. It won't be easy here, but they will get a road victory. 

Pick: Panthers 20, Jets 17


Chicago at Philadelphia

1 p.m. ET (Fox)

This will be a tough challenge for Bears rookie quarterback Mitchell Trubisky facing that Eagles pass rush. Philadelphia is also playing well on offense with Carson Wentz. I think they handle the Bears easily in this one. 

Pick: Eagles 30, Bears 14


New Orleans at Los Angeles Rams 

4:25 p.m. ET (CBS)

This is the game of the week, but it's a long trip for the Saints. They rallied last week to win behind Drew Brees, and I think they will need him here in a big way. This could be a fun shootout between the old guy in Brees against the new guy in Jared Goff. I think Brees will get the best of it.

Pick: Saints 28, Rams 24


Seattle at San Francisco

4:05 p.m. ET (Fox)

The Seahawks sure haven't looked like the team we expected to see this season as injuries have crippled the defense. But that won't matter here. The 49ers aren't good on offense, and that will show up. Plus, Russell Wilson will have a big day. Seattle takes it. 

Pick: Seahawks 30, 49ers 14


Jacksonville at Arizona

4:25 p.m. ET (CBS)

This is a second straight road game for a young team, which is always tough. But the Jaguars have a dominant defense that travels. They will be facing former Jaguars quarterback Blaine Gabbert for the Cardinals. I think their pass rush is too much for Gabbert and they keep on winning. 

Pick: Jaguars 21, Cardinals 14


Denver at Oakland 

4:25 p.m. ET (CBS)

Both teams have been major disappointments this season and the Broncos are basically done. Oakland needs to get it going to have any playoff chance, and this could be the week. But I think Denver plays a good game here to keep it close with Oakland winning.

Pick: Raiders 23, Broncos 20


Green Bay at Pittsburgh 

8:30 p.m. ET (NBC)

This looked like it would be a big game when the schedule came out, but with Aaron Rodgers out it's not that way now. The Steelers played well in beating the Titans last Thursday and they will continue to do so here. Ben Roethlisberger will have another good outing, while Brett Hundley will not. 

Pick: Steelers 30, Packers 10


Houston at Baltimore

Monday, 8:30 p.m. ET (ESPN)

The Ravens would be the sixth seed if the playoffs started today, which means this is a big one for them. The defense has been outstanding as of late. That will continue here against the Texans and Tom Savage. Ravens take it. 

Pick: Ravens 24, Texans 13

Thanksgiving leftovers

Minnesota at Detroit

This is a big Thanksgiving Day game, which we love. The Vikings are in first place, and if the Lions are to have a chance to win the division they have to win here. I don't think the Lions will move the ball well enough against the Vikings defense. And Case Keenum is playing well for the Vikings. Minnesota takes it.

Pick: Vikings 23, Lions 17

Result: Vikings 30, Lions 23 (RECAP)


Los Angeles Chargers at Dallas 

The Cowboys have issues on offense with no Ezekiel Elliott or Tyron Smith, who is questionable here. The Chargers have a lethal pass rush with Joey Bosa and Melvin Ingram that could be a major problem for the Cowboys. Chargers take it in an upset as they limit the Dallas offense. 

Pick: Chargers 27, Cowboys 21

Result: Chargers 28, Cowboys 6 (RECAP)


New York Giants at Washington

The Giants showed some life last week in upsetting the Chiefs. I expect them to be feisty here too against their division rival. The Redskins need to win here to have any real playoff shot. The Giants will make it close, but Washington finds a way. 

Pick: Redskins 20, Giants 17

Result: Redskins 20, Giants 10 (RECAP)

CBS Sports Senior Writer

Pete Prisco has covered the NFL for three decades, including working as a beat reporter in Jacksonville for the Jaguars. When he's not watching game tape, you can find Pete on Twitter or dreaming of an... Full Bio

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