A tumultuous week for Jaguars coach Urban Meyer moves to the football field on Sunday when Jacksonville hosts the Tennessee Titans at TIAA Bank Field. Jacksonville will try to end its 19-game losing streak, the third longest in NFL history. Tennessee is a 4.5-point favorite in the latest NFL odds from Caesars Sportsbook, but can you trust a rookie quarterback and first-year head coach in your NFL bets and NFL parlays?

Other key NFL games this week include the Chiefs and Bills battling on Sunday Night Football in a rematch of last season's AFC Championship Game and the 3-1 Chargers hosting the 3-1 Browns. Before making any Week 5 NFL picks or predictions, you need to check out the NFL best bets from the proven computer model at SportsLine. 

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 5. If you successfully parlay its picks, you would be looking at a massive payout of 20-1. You can only see the model's Week 5 NFL picks at SportsLine. 

Top Week 5 NFL picks

After simulating every NFL game 10,000 times, the model is high on the Cardinals to cover as five-point favorites at home against the 49ers. The Cardinals (4-0) have emerged as the league's biggest surprise through four weeks. They are the NFL's lone unbeaten team after handily beating the previously unbeaten Rams last week, 37-20. San Francisco (2-2) is on a two-game losing streak after dropping decisions to Green Bay and Seattle.

The Cardinals have the most red zone touchdowns in the NFL, scoring touchdowns on 13-of-18 red zone drives. They'll face a defense that has had issues in the red zone, allowing 11 touchdowns on 14 drives past the 20-yard-line, tied for second-most red zone touchdowns allowed with Philadelphia and Green Bay.

How to make Week 5 NFL parlays

The model also jumped on four other matchups where it says the line is off, including a divisional battle and a game between two playoff teams from a season ago. You can only see the model's NFL Week 5 best bets at SportsLine. 

What are the model's top Week 5 NFL picks? And which other matchups should you target for a 20-1 payout? Visit SportsLine now to see the Week 5 NFL best bets from a model on a 124-82 run on its top-rated picks, and find out.