Dupree (neck) is off the Chargers' injury report ahead of the team's matchup versus the Rams on Sunday.
Dupree missed the team's Week 6 loss to the Chiefs due to a neck injury but is now healthy again. The 2015 first-round pick has compiled five tackles (two solo) across five outings this season and should continue to serve as a rotational defender against the Rams.
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Chargers' Denzel Perryman: Progressing in recovery
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Head coach Jim Harbaugh said Wednesday that Perryman (undisclosed) is "close" to returning from injured reserve, Alex Insdorf of BoltBeat.com reports.
Harbaugh added that Perryman isn't quite ready to return to practice, and given that the veteran linebacker's 21-day practice window has yet to open, he's probably not available for Sunday's game against the Rams. Perryman landed on IR on Sept. 1 due to an undisclosed injury that he may have picked up toward the tail end of training camp.
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Chargers' Deane Leonard: Doesn't practice due to concussion
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Leonard (concussion) did not participate in Wednesday's practice, Alex Insdorf of BoltBeat.com reports.
It is unclear when Leonard sustained his concussion, as the Chargers were on bye in Week 7. The depth cornerback has enterted the NFL's five-step concussion protocol and will not be able to suit up for full-contact activities until he is cleared by an independent neurologist.
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Chargers' Derwin James: Suffers hamstring setback
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James (hamstring) suffered a setback in his recovery and will likely miss Sunday's game against the Rams, Eric Smith of the Chargers' official site reports.
James is a candidate for injured reserve and could be out for some time with a persistent hamstring injury. The star strong safety has also been discussed in trade rumors as the 0-6 Chargers' season appears to be all but over. Tony Jefferson is set to start at strong safety in Sunday's game against the Rams.
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Chargers' Rodney Shelley: Unavailable against Kansas City
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Shelley (hamstring) won't suit up for Sunday's game against the Chiefs.
Shelly didn't play in Week 5 against the Broncos. He was listed as doubtful heading into the meeting with Kansas City but will now miss his second consecutive contest. With Donte Jackson (hamstring) also sidelined, Deane Leonard is the favorite to start opposite Cam Hart at corner.
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Chargers' Bud Dupree: Sidelined for Week 6
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Dupree (neck) won't play in Sunday's game against Kansas City.
Dupree suffered a neck injury in the Week 5 meeting with the Broncos. He practiced in a limited capacity a few times during the week but ended up receiving a questionable tag. Now that Dupree has been ruled out, rookie Akheem Mesidor is in line for more snaps.
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Chargers' Daiyan Henley: Active for Week 6
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Henley (knee) is active for Sunday's game against the Chiefs.
Henley was listed as questionable for Sunday's game due to a knee injury. The linebacker was limited in practice all week due to the injury but has recovered enough to suit up for the Chargers' Sunday divisional contest against the Chiefs.
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Chargers' Rodney Shelley: Unlikely to play against Kansas City
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Shelley (hamstring) is listed as doubtful for Sunday's game against the Chiefs.
It looks like Shelley will miss a second consecutive game due to a hamstring injury, which he has worked through for most of the regular season. With Donte Kackson (hamstring) already ruled out, Deane Leonard figures to start opposite Cam Hart at outside cornerback, assuming Shelley is also inactive.
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Chargers' Derwin James: Sidelined for Week 6
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James (hamstring) has been ruled out for Sunday's game against the Chiefs.
James was not cleared to practice all week due to a hamstring injury, which will cause him to miss a second-straight week. The Chargers are on a bye for Week 7, so the veteran safety will have additional time to rest ahead of Week 8 against the Rams on Sunday, Nov. 1. Elijah Molden, Tony Jefferson and Genesis Smith are all in line for more defensive snaps in the secondary in James' absence.
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Chargers' Donte Jackson: Won't play against Kansas City
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Jackson (hamstring) has been ruled out ahead of Sunday's game against the Chiefs.
Jackson will end up missing a second consecutive game due to a hamstring injury he sustained in Week 4 against the Seahawks. He hasn't been cleared to return to practice since sustaining the injury, but with the Chargers on a bye for Week 7, Jackson will have additional time to rest before Week 8 against the Rams on Sunday, Nov. 1. With Rodney Shelley (hamstring) listed as doubtful, Deane Leonard will likely start at outside cornerback Cam Hart in Jackson's absence.
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Chargers' Daiyan Henley: Iffy for Week 6
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Henley (knee) is listed as questionable for Sunday's game against the Chiefs.
Henley was a limited practice participant all week due to a knee injury, which he likely picked up during the Chargers' Week 5 loss to the Broncos. Troy Dye would likely start alongside Del'Shawn Phillips at inside linebacker if Henley is not cleared to play against Kansas City.
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Chargers' Derwin James: Absent from practice Thursday
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James (hamstring) did not practice Thursday.
James has missed the Chargers' last two games because of a hamstring injury. He hasn't practiced all week, so chances are he is heading toward a third consecutive absence. If James can't suit up for the Week 6 meeting with the Chiefs, Tony Jefferson and Genesis Smith may remain more involved.
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Kyle Kennard: Tries out with Colts
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Kennard (undisclosed) tried out with Colts on Tuesday, Aaron Wilson of KPRC 2 Houston reports.
Kennard is healthy again after being waived from the Chargers' injured reserve last month with an injury settlement. The 24-year-old tallied just two tackles (one solo) across five games with the Chargers last season and will look to catch on with the Colts or another team.
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Chargers' Bud Dupree: Exits with neck injury
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Dupree (neck) is questionable to return to Sunday's game against the Broncos.
Dupree exited the third quarter of Sunday's contest with a neck injury. Akheem Mesidor will be the sole rotational option at outside linebacker while Dupree is evaluated.
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Chargers' Rodney Shelley: Inactive in Week 5
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Shelly (hamstring) is inactive for Sunday's game versus the Broncos, Eric Smith of the team's official site reports.
Shelly has been dealing with the hamstring injury for at least a few weeks. After suiting up in the Chargers' first four games of the 2026 campaign, he will finally sit out in Week 5 against Denver.
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Chargers' Scott Matlock: Active versus Denver
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Matlock (foot) is active for Sunday's game against the Broncos, Eric Smith of the team's official site reports.
Matlock was activated off injured reserve Saturday, so despite carrying a questionable designation, most assumed he would be back on the field after sitting out the first four games of the 2026 campaign.
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Chargers' Scott Matlock: Taken off injured reserve
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The Chargers activated Matlock (foot) from injured reserve Saturday, but he's still listed as questionable for Sunday's game against the Broncos.
Matlock was designated to return from injured reserve Wednesday, and he drew the questionable tag after logging a full practice Friday. The fact that he was activated from IR indicates that Matlock has a good chance of making his 2026 regular-season debut Sunday.
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Chargers' Donte Jackson: Won't play versus Denver
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Jackson (hamstring) has been ruled out for Sunday's game against the Broncos.
Jackson was held out of practice all week due to a hamstring injury, which he picked up during the Chargers' Week 4 loss to the Seahawks. His next chance to play is Week 6 against the Chiefs, but in his absence, Deane Leonard and Rodney Shelley are the top candidates to start at outside cornerback opposite Cam Hart.
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Chargers' Donte Jackson: Misses practice Wednesday
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Jackson (hamstring) did not practice Wednesday, Kris Rhim of ESPN.com reports.
Jackson was in concussion protocol and listed as questionable ahead of the Week 4 meeting with Seattle. While he managed to get on the field, he exited the contest due to a hamstring issue and didn't return. It's possible Jackson didn't practice Wednesday as a precaution, so he'll have a few more chances to get out there. For now, the 30-year-old should at least be considered questionable for the Week 5 matchup with Denver.
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Chargers' Tuli Tuipulotu: Secures interception in loss
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Tuipulotu recorded six total tackles (three solo), including 0.5 sacks, while intercepting a pass and forcing a fumble during Sunday's 30-23 loss to Seattle.
Tuipulotu jumped in front of quarterback Sam Darnold's first pass of the day, notching his first career interception. The linebacker later stripped running back Emanuel Wilson in the third quarter, but Wilson fell on the fumble. Tuipulotu also combined with defensive lineman Justin Eboigbe to sack Darnold in the fourth quarter. The 24-year-old has now compiled 18 total tackles (11 solo), including 2.0 sacks, while also adding an interception and a forced fumble over four contests this season.
