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Sports fans interested in wagering on Monday Night Football can do so with the latest Caesars Sportsbook promo code CBS250BM, which gives users a first bet match up to $250. Week 16 of the 2025 NFL season concludes with the San Francisco 49ers visiting the Indianapolis Colts on Monday Night Football. Click here to sign up for Caesars Sportsbook to bet on Monday's top games:

For a full breakdown of terms and conditions, check out the Caesars Sportsbook promo code review page.

Best bets for Monday, Dec. 22

The 49ers have a chance to not only extend their winning streak, but remain in position for the No. 1 seed in the NFC. Brock Purdy and George Kittle have returned to form after missing time with injuries, while Christian McCaffrey remains one of the league's most dynamic offensive players. The Colts are hoping for some magic from future Hall of Fame quarterback Philip Rivers, who came out of retirement to help this team finish out the year after Daniel Jones suffered a season-ending Achilles injury. The 49ers are 5.5-point favorites in the latest SportsLine consensus odds, but the model is backing the Colts. Indianapolis covers the spread in 53% of simulations.

On the hardwood, the Detroit Pistons hope to maintain their standing as the top team in the Eastern Conference when they take on the Portland Trail Blazers on Monday. The Blazers have won three in a row as they attempt to get into the Western Conference playoff picture with Deni Avdija, Shaedon Sharpe and Jerami Grant leading the way. Grant is questionable for Monday's contest. Detroit has won five of its last six games and should have double-double machine Jalen Duren for this contest, as he is probable. The SportsLine Projection Model likes the home team in this one, as Portland covers the 5.5-point spread in 56% of simulations.

Bet on 49ers-Colts, Pistons-Trail Blazers and more at Caesars here:

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