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The Louisville Cardinals will look to stay unbeaten against Southland Conference opponents when they take on the Southeastern Louisiana Lions in a nonconference matchup on Tuesday. The Cardinals (6-3), who are coming off a 62-55 loss to DePaul on Friday, placed seventh in the ACC at 8-5 and were 13-7 overall last season. The Lions (4-6), who were beaten 72-66 at Southern on Saturday, were ninth in the Southland Conference at 5-10 and were 8-18 overall in 2020-21. The game will be the first between the Cardinals and Lions.

The game from KFC Yum! Center in Louisville, Ky., is scheduled to tip off at 6 p.m. ET. The Cardinals are 23.5-point favorites in the latest Southeastern Louisiana vs. Louisville odds from Caesars Sportsbook, while the over-under for total points scored is set at 140.5. Before locking in any Louisville vs. Southeastern Louisiana picks, make sure you check out the college basketball predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisville vs. SE Louisiana and just locked in its picks and CBB predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and betting lines for SE Louisiana vs. Louisville:

  • Louisville vs. Southeastern Louisiana spread: Louisville -23.5
  • Louisville vs. Southeastern Louisiana over-under: 140.5 points
  • Louisville vs. Southeastern Louisiana money line: Louisville -4000, SE Louisiana +1400
  • SELA: The under is 4-0 in the Lions' last four Tuesday games
  • LOU: The Cardinals are 5-1 against the spread in their last six games following a straight-up loss

Why Louisville can cover 

Sophomore guard/forward Dre Davis is a big part of the Cardinals' offense, averaging 8.8 points, 4.6 rebounds and 1.2 assists per game. He is an 80 percent free throw shooter. Davis has reached double-digit scoring in four games, including two of his last three games. His best performance was an 18-point, nine-rebound game against Detroit on Nov. 20. Davis started in 17 games as a freshman, averaging 7.4 points and 3.2 rebounds. He was named to the 2021 All-ACC Academic team.

Sophomore transfer forward Matt Cross is coming off back-to-back double-digit performances, scoring 11 points in Friday's loss to DePaul and 13 points at North Carolina State on Dec. 4. He has reached double figures four times this season, including a 15-point performance in a season-opening 72-60 win over Southern on Nov. 9. For the year, Cross is averaging 7.8 points and 3.4 rebounds per game. Last season at Miami, Fla., he played in 14 games, including nine starts, and averaged 6.9 points and 3.5 rebounds, making 20 of 50 3-point field goals.

Why Southeastern Louisiana can cover

The Lions have eight players averaging 5.5 points or more. Leading the way is junior guard Gus Okafor at 13.5 points. He is also averaging 5.6 rebounds, 1.8 assists and 1.2 steals. Okafor has reached double figures in seven games this season, recording two double-doubles. He scored a season-high 23 points in a 90-71 loss against Florida Gulf Coast on Nov. 27.

Senior forward Jalyn Hinton is also a solid offensive option for the Lions and is coming off a 14-point, seven-rebound performance in Saturday's loss at Southern. He is averaging 12.4 points, 7.2 rebounds, 2.1 blocks, 1.8 assists and 1.1 steals in his first year at Southeastern Louisiana. Hinton has reached double figures in nine games and has recorded two double-doubles. Prior to Southeastern, he averaged 20.1 points, 10.1 rebounds and 3.6 blocked shots in 12 games at Division II Florida Southern in a COVID-19-shortened 2020-21.

How to make Southeastern Louisiana vs. Louisville picks

SportsLine's model is leaning over on the total, projecting 141 combined points. It has also generated an against-the-spread pick that cashes in over 70 percent of simulations. You can only get the model's pick at SportsLine. 

So who wins Louisville vs. SE Louisiana? And which side of the spread hits in over 70 percent of simulations? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up over $2,400 on its college basketball picks the last five years, and find out.