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The No. 21 Xavier Musketeers and the Butler Bulldogs will face off in a Big East clash at 7 p.m. ET Wednesday at Cintas Center. The Musketeers are 15-5 overall and 10-2 at home, while Butler is 11-10 overall and 2-3 on the road. Xavier has won three of the last four matchups between the teams.

The Musketeers are favored by 11.5 points in the latest Xavier vs. Butler odds from Caesars Sportsbook, and the over-under is set at 130.5. Before entering any Butler vs. Xavier picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Xavier vs. Butler. You can head to SportsLine to see its picks. Here are several college basketball odds for Butler vs. Xavier:

  • Xavier vs. Butler spread: Xavier -11.5
  • Xavier vs. Butler over-under: 130.5 points

What you need to know about Xavier

Xavier beat the Creighton Bluejays 74-64 this past Saturday. The Musketeers were down by 17 points at halftime but outscored Creighton 55-28 in the second half. Xavier got double-digit scores from four players: guard Paul Scruggs (18), forward Zach Freemantle (16), forward Jack Nunge (16), and guard Nate Johnson (15).

Nunge, Scruggs and Johnson are three of the four Musketeers averaging in double figures, along with Colby Jones. Nunge leads the team with 12.7 points per game, despite starting just three of 20 games this season. Nunge will be hoping for a better game this time around against Butler as the last time he faced it a few weeks ago, he scored just eight points and missed both his 3P attempts.

What you need to know about Butler

Meanwhile, things were close when Butler and the Georgetown Hoyas clashed this past Saturday, but Butler ultimately edged out the opposition 56-53. The Bulldogs' forward Bryce Nze filled up the stat sheet, dropping a double-double on 12 points and 12 boards along with three blocks.

The Bulldogs have struggled putting the ball into the hoop this year, ranking 339th out of 358 teams in points per game. They have just one player averaging in double figures as Chuck Harris is putting up 10.6 points per game. He scored just six points when Butler last faced Xavier in January, while Aaron Thompson, who averages 7.5 PPG, led the Bulldogs with 20 points.

How to make Butler vs. Xavier picks

The model has simulated Xavier vs. Butler 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Butler vs. Xavier? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the Xavier vs. Butler spread to jump on, all from the advanced model that is up more than $2,400 on its college basketball picks the last five years, and find out.