DraftKings betting picks, best Week 2 college football bets: How to bet Michigan vs. Oklahoma and more

SportsLine's model reveals its top Week 2 college football picks and CFB predictions at DraftKings

By Richard Louis

Sep 6, 2025 at 8:38 am ET • 3 min read

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The second week of the 2025 college football season continues on Saturday, and fans should use the latest DraftKings promo code, offering over $200 off on NFL Sunday Ticket as well as $300 in bonus bets. There will be matchups throughout the day, including Iowa vs. No. 16 Iowa State, No. 20 Ole Miss vs. Kentucky, and No. 15 Michigan vs. No. 18 Oklahoma. DraftKings is the perfect outlet to get you prepared for this Week 2 slate of college football. The Cyclones are favored by 3.5 points in the latest Week 2 college football odds, while Ole Miss is an 8.5-point favorite over Kentucky.

SportsLine's computer model is taking the Michigan vs. Oklahoma Over (43.5) as one of its top college football predictions this week. Before locking in your Week 2 college football picks on your favorite betting sites like DraftKings, you'll also want to be sure to check out the top college football betting picks from SportsLine's proven computer model. Claim the latest DraftKings bonus code here, where new users get $300 in bonus bets, in addition to more than $200 off NFL Sunday Ticket:

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks on betting sites could have seen strong returns.

Best Week 2 college football picks:

Over 43.5 total points: Michigan vs. Oklahoma
Iowa (+3.5) vs. Iowa State
Ole Miss Over 26.5 points vs. Kentucky

Combining the model's three picks into a Week 2 college football parlay at DraftKings would result in a payout of +415 (risk $100 to win $415). Bet it at DraftKings here:

Michigan vs. Oklahoma: Over 43.5 total points

This top-20 showdown has the Michigan Wolverines traveling to match up against the Oklahoma Sooners. In his freshman quarterback Bryce Underwood's debut, he led Michigan to a 34-17 win over New Mexico. The Wolverines had 452 total yards, with Underwood going 21-of-31 for 251 yards and a passing touchdown. Meanwhile, the Sooners poured in 35 points. Quarterback John Mateer had 392 passing yards, 24 rushing yards, and four total touchdowns. SportsLine's model has these teams combining for 47 total points on Saturday.

Iowa +3.5 vs. Iowa State

The in-state rivalry between Iowa and Iowa State is set to kick off at noon ET. The Hawkeyes secured a commanding 34-7 win over UAlbany in Week 1. Meanwhile, the Cyclones dominated South Dakota en route to a 55-7 victory on Aug. 30. In school history, the Hawkeyes own a 47-23 advantage over Iowa State. While Iowa State has won two of the past three matchups, Iowa has lost by three points or less in both losses. SportsLine's model has the Hawkeyes covering the spread in 58% of the simulations.

Ole Miss Over 26.5 points vs. Kentucky

The Ole Miss offense racked up 63 points and 695 total yards of offense in their Week 1 victory over Georgia State. While they won't be able to move the ball in the same manner going up against an SEC opponent, the Rebels' offense has a bunch of playmakers. Quarterback Austin Simmons had 341 passing yards and three touchdowns in Week 1. Running back Kewan Lacy had 108 rushing yards and three touchdowns on the ground, with Harrison Wallace III reeling in 130 receiving yards and a score. SportsLine's model has Ole Miss scoring 33 points on the road in Saturday's matchup.