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The Central Michigan Chippewas aim to pull off a road upset against the No. 12 Oklahoma State Cowboys on Thursday evening. Central Michigan won the last matchup between the programs in 2016, and the Chippewas are on an active five-game winning streak. Central Michigan posted a 9-4 record last season, with Oklahoma State coming in at 12-2. The Cowboys were 7-0 at home last season, and the game is set for Boone Pickens Stadium in Stillwater, Okla.

Caesars Sportsbook lists Oklahoma State as a 21.5-point favorite at home, and kick-off is scheduled for 7 p.m. ET. The total number of points Vegas thinks will be scored, or the over-under, is 58 in the latest Oklahoma State vs. Central Michigan odds. Before you make any college football predictions with the Oklahoma State vs. CMU match-up, you need to see the college football predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Central Michigan vs. Oklahoma State and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for Oklahoma State vs. Central Michigan:

  • Oklahoma State vs. Central Michigan spread: OK State -21.5 
  • Oklahoma State vs. Central Michigan over/under: 58 points 
  • Oklahoma State vs. Central Michigan money line: OK State -1700, CMU +950
  • CMU: The Chippewas won more games in 2022 than in any season since 2009 
  • OSU: The Cowboys have won 12 straight against non-Power 5 opponents 
  • Oklahoma State vs. Central Michigan picks: See picks here.

Why Central Michigan can cover

The Chippewas are coming off an impressive 2021 season with nine wins and a victory over Washington State in a bowl setting. Central Michigan is on an active five-game winning streak, the third-longest stretch in FBS, and the Chippewas are 20-13 since Jim McElwain took over, the best record in the MAC. That includes tremendous against-the-spread success at 21-11-1 since 2019, and the offense returns a great deal from last season. 

Central Michigan ranked in the top 25 of the country in total offense in 2021, including the second-best passing offense in the MAC. Daniel Richardson returns as the starter at quarterback after a 24-touchdown season with more than 2,600 passing yards, and he protected the ball with only six interceptions. From there, Central Michigan has one of the best running backs in the country in Lew Nichols III, who led FBS with 1,848 rushing yards last season with 10 touchdowns and at least 100 rushing yards in each of Central Michigan's last eight games.

Why Oklahoma State can cover

Oklahoma State has enjoyed tremendous success in the recent past, including the best against-the-spread record (25-12-1) in FBS since the start of the 2019 season. Mike Gundy's program has a 16-year bowl streak, and Oklahoma State is 28-1 in the last 29 games against non-Power 5 opponents. The Cowboys return an experienced starting quarterback in Spencer Sanders, who has a 24-8 record at the helm in Stillwater, and Oklahoma State posted a 7-0 home mark in 2021. From there, Oklahoma State's defense was elite a year ago, and the Cowboys face a Central Michigan team that lost a pair of offensive tackles to the NFL.

Oklahoma State allowed only 18.1 points per game last season, fewest by a Big 12 program since 2010, and the Cowboys were in the top 10 nationally in scoring defense. That resistance was headlined by the second-most sacks (56) in the country, and Oklahoma State also led the Big 12 in total defense, giving up fewer than 300 yards per game. The Cowboys return elite depth at defensive end with Collin Oliver, Brock Martin, and Tyler Lacy, and Oklahoma State's run defense is well-suited to slow down Central Michigan's impressive rushing attack.

How to make Central Michigan vs. Oklahoma State picks

SportsLine's model is leaning Under on the total, with the teams projected to score a combined 51 points. The model also says one side of the spread hits in well over 60 percent of simulations. You can only see the model's CFB picks at SportsLine.

So who wins Oklahoma State vs. Central Michigan? And which side of the spread hits in well over 60 percent of simulations? Visit SportsLine now to see which side of the Central Michigan vs. Oklahoma State spread you need to jump on Thursday, all from the model that has crushed its college football picks, and find out.