Meadows went 1-for-2 with a walk-off, three-run home run and two walks in Friday's 4-1 victory over the Astros.
The Tigers tied the game with three straight singles off Houston closer Ryan Pressly before Meadows delivered the knockout blow with his first major-league home run. They were also the first three RBI of his brief big-league career in his fourth game for Detroit. The rookie outfielder has reached base eight times in those four contests.